InvivoGen provides an expanding collection of full-length sequenced genes involved in inflammasomes.
Inflammasomes are multimeric protein complexes that are crucial for host defense against infection and response to endogenous danger signals. The canonical inflammasome response is driven by the aggregation of a sensor, such as NLRP3, with the ASC adaptor and pro-caspase-1. Activation of caspase-1 (CASP1) induces the maturation of pro-IL-1β/pro-IL-18 and cleavage of the pore-forming protein gasdermin D (GSDMD). Subsequent GSDMD pore formation at the cell membrane elicits a rapid cell death associated with the release of IL-1β, IL-18, and High Mobility Group Box-1 (HMGB1).