Inflammasomes are multiprotein platforms that induce a complex signaling cascade resulting in the activation of inflammatory caspases (caspase-1 and caspase 11-4/5).
Inflammasome activation triggers the maturation and secretion of IL-1β and IL-18, as well as the release of alarmins through the formation of gasdermin D (GSDMD) pores at the surface membrane. Ultimately, the accumulation of GSDMD pores leads to an inflammatory cell death called pyroptosis.
InvivoGen offers a selection of inhibitors to block inflammasome-induced responses.
You may choose among:
Caspase-1 or pan-caspase inhibitors
NLRP3 inflammasome inhibitors
- Multi-target inhibitors
Read our review on the NLRP3 inflammasome.
All inflammasome inhibitors provided by InvivoGen are endotoxin-free and validated using THP1-HMGB1-Lucia™ cells to activate the inflammasome, and HEK-Blue™ IL-1β cells to measure the release of bioactive IL-1β.