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Inflammasome Inhibitors

Inhibitors targeting inflammasome pathways
Inhibitors targeting inflammasome pathways

 

Inflammasomes are multiprotein platforms that induce a complex signaling cascade resulting in the activation of inflammatory caspases (caspase-1 and caspase 11-4/5).
Inflammasome activation triggers the maturation and secretion of IL-1β and IL-18, as well as the release of alarmins through the formation of gasdermin D (GSDMD) pores at the surface membrane. Ultimately, the accumulation of GSDMD pores leads to an inflammatory cell death called pyroptosis.
 

InvivoGen offers a selection of inhibitors to block inflammasome-induced responses.
You may choose among:
 

  • Caspase-1 or pan-caspase inhibitors
     
  • NLRP3 inflammasome inhibitors
     
  • Multi-target inhibitors

 

Read our review on the NLRP3 inflammasome.

 

All inflammasome inhibitors provided by InvivoGen are endotoxin-free and validated using THP1-HMGB1-Lucia™ cells to activate the inflammasome, and HEK-Blue™ IL-1β cells to measure the release of bioactive IL-1β.

 

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