RLR Pathway Inhibitors

InvivoGen provides inhibitors of the RIG-I-Like receptors (RLRs) signaling pathway.

This family comprises:

• Inhibitors targeting TBK1/IKKε

TANK-binding kinase 1 (TBK1) and I-kappa-B kinase epsilon (IKKε) are essential for the intracellular signaling downstream of multiple pattern-recognition receptors (PRRs), including the RLRs. These noncanonical IκB kinase homologs are crucial in the interferon (IFN) regulatory factor 3 (IRF3) and IRF7 signaling pathways and the subsequent expression of IFN-stimulated genes.

These inhibitors are chemically synthesized and are characterized by UHPLC and mass spectrometry. For each lot, the biological activity is validated and the absence of bacterial contamination (e.g. endotoxins) is verified using cell-based assays.