InvivoGen provides an extensive list of tools to study RIG-I-like receptors
RIG-I-like receptors (RLRs) are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA.
RIG-I (retinoic-acid-inducible protein 1) and MDA5 (melanoma-differentiation-associated gene 5) sense double-stranded RNA (dsRNA), a replication intermediate for RNA viruses. LGP2 (aka DHX58) contains an RNA binding domain but acts as a negative feedback regulator of RIG-I and MDA5. Typically, activated RIG-I or MDA5 are recruited by the adaptor protein MAVS (mitochondrial antiviral signaling protein, aka IPS1 or VISA), leading to IFN regulatory factor (IRF3 and IRF7)-dependent type I IFN production and NF-κB-dependent inflammatory cytokine production.
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Choosing from our growing collection
- RLR reporter cells
- A comprehensive choice of RLR ligands
- RLR pathway inhibitors
- fully-sequenced RLR and related genes
Key features of InvivoGen's products
- Cell lines from various tissue origins (THP-1, A549, HEK 293, RAW cells)
- Each lot is functionally tested
- Guaranteed free of unwanted bacterial contaminants
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RLR signaling pathways