RIG-I-Like Receptors - RLRs
RIG-I-like receptors (RLRs) constitute a family of three cytoplasmic RNA helicases that are critical for host antiviral responses.
RIG-I and MDA-5 sense double-stranded RNA (dsRNA), a replication intermediate for RNA viruses, leading to production of type I interferons (IFNs) in infected cells. LGP2 contains a RNA binding domain but lacks the CARD domains and thus acts as a negative feedback regulator of RIG-I and MDA-5.
InvivoGen offers a large set of tools to study RIG-I-Like Receptors: RLR reporter cell lines, an expanding collection fo RLR ligands, shRNAs as RLR inhibitors, and fully sequenced RLR and related genes.