InvivoGen provides a set of tools to study AhR signaling
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor widely expressed among immune, epithelial, endothelial, and stromal cells in barrier tissues.
While historically studied in the context of chemical pollutants such as dioxin, AhR was also revealed as a central sensor of a wider range of environmental cues, such as dietary-derived compounds, ensuring intestinal homeostasis between the host and gut microbiota.
On the one hand, AhR activation by dietary ligands shapes the intestinal bacterial composition. On the other hand, AhR sensing regulates homeostasis and functionality of the gut immune cells. Understanding AhR's role in environmental toxicity will help assess the impact of pollutants on human health.
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InvivoGen's collection of tools to screen for AhR ligands:
- AhR reporter cell lines
- FICZ, a tryptophan-derived agonist of AhR
- AhR antagonist
- AhR genes, fully sequenced in expression plasmids
Key features of InvivoGen's AhR products
- Cell lines from various tissue origins (HepG2, HT29 cells)
- Each lot is functionally tested
- Guaranteed free of unwanted bacterial contaminants
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AhR role in the intestine