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Aryl Hydrocarbon Receptor - AhR

AhR role in intestine

 

The aryl hydrocarborn receptor (AhR) is a ligand-dependent transcriptional factor widely expressed among immune, epithelial, endothelial and stromal cells in barrier tissues.

While historically studied in the context of chemical pollutants such as dioxin, AhR was more recently revealed as a central sensor of a wider range of environmental cues, such as dietary-derived compounds, ensuring intestinal homeostasis between the host and gut microbiota.

On the one hand, AhR activation by dietary ligands shapes the intestinal bacterial composition. On the other hand, AhR sensing regulates homeostasis and functionality of the gut immune cells.

 

InvivoGen’s offers a collection of tools to screen for AhR ligands and to study the AhR genomic signaling pathway:

  • AhR reporter cell lines
  • a selection of dietary-derived AhR agonists
  • a synthetic AhR antagonist

 

 

Read our review on AhR’s key role in the intestinal microbiota and immunity

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