Tissue-specific Promoters

Tissue Specific Promoters are active in a specific type of cells or tissues such as B cells, monocytic cells, leukocytes, macrophages, muscle, pancreatic acinar cells, endothelial cells, astrocytes, lung...

Tissue Specific Promoters are available as native or composite promoter:

  • Native promoters,  also called minimal promoters,  consist of a single fragment from the  5’ region of a given gene. Each of  them comprises a core promoter and  its natural 5’UTR. In some cases,  the 5’UTR contains an intron.
  • Composite promoters combine promoter elements of different origins or were generated by assembling a distal enhancer with a   minimal promoter of the same origin.

In each pDRIVE, the promoter drives the expression of a reporter gene to   facilitate the evaluation of its activity.

Three different reporter  genes  are available in two different backbones: LacZ reporter gene in  pDRIVE, secreted embryonic alkaline phosphatase (SEAP) or Lucia secreted luciferase reporter gene in pDRIVE5.

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