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pDRIVE-Mb

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hMb

pDRIVE bearing human Mb promoter - LacZ

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20 µg

pdrive-hmb
+-
$554

pDRIVE5SEAP-hMb

pDRIVE bearing human Mb promoter - SEAP

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20 µg

pdrive5s-hmb
+-
$554

pDRIVE5Lucia-hMb

pDRIVE bearing human Mb promoter - Lucia

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20 µg

pdrive5lc-hmb
+-
$554

pDRIVE-mMb

pDRIVE bearing mouse Mb promoter - LacZ

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20 µg

pdrive-mmb
+-
$554

pDRIVE5SEAP-mMb

pDRIVE bearing mouse Mb promoter - SEAP

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20 µg

pdrive5s-mmb
+-
$554

pDRIVE5Lucia-mMb

pDRIVE bearing mouse Mb promoter - Lucia

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20 µg

pdrive5lc-mmb
+-
$554

Mb promoter (Muscle) in pDRIVE expression plasmid

Myoglobin is a cytoplasmic hemoprotein that binds molecular oxygen to facilitate its diffusion from the vascular system to the muscle mitochondria.

Myoglobin is found only in muscle, predominantly in cardiac and skeletal myocytes.

he myoglobin promoter can drive the expression of a transgene in multinucleated myotubes but not in  mononucleated and undifferentiated cells [1].

This capacity is conferred by a small segment of the 5’ flanking region extending from nucleotides -357 to +55 relative to the transcriptional start site [2].

 

References:

1. Devlin BH. et al. 1989. Identification of a muscle-specific enhancer within the 5’-flanking region of the human myoglobin gene. J Biol Chem 264(23):13896-13901.
2. Yan Z. et al. 2001. Regulatory elements governing transcription in specialized myofiber subtypes. J Biol Chem 276(20):17361-17366.

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Specifications

pDRIVE bearing human Mb promoter - LacZ, SEAP or Lucia

Gene Promoter: Myoglobin

Specificity: Muscle

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

pDRIVE bearing mouse Mb promoter - LacZ, SEAP or Lucia

Gene: Myoglobin

Specificity: Muscle

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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