iE-DAP and Derivatives
NOD1 (CARD4) is a member of the family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats. NOD1 is an intracellular pattern-recognition molecule involved in the recognition of peptidoglycan (PGN). NOD1 senses the iE-DAP dipeptide which is found in PGN of all Gram-negative and certain Gram-positive bacteria.
InvivoGen provides iE-DAP, the minimal motif recognized by NOD1, and iE-DAP derivatives that stimulate NOD1 at concentrations lower than the original iE-DAP. The functionality of these NOD1 ligands is validated using HEK-Blue™ NOD1 Cells.