Tri-DAP - NOD1 Agonist

NOD1 Agonist - L-Ala-gamma-D-Glu-mDAP

L-Ala-γ-D-Glu-mDAP (Tri-DAP) comprises the iE-DAP (γ-D-Glu-mDAP) dipeptide and a L-Ala residue. Tri-DAP is present in the peptidoglycan (PGN) of Gram-negative bacilli and certain Gram-positive bacteria.

Tri-DAP is recognized by the intracellular sensor NOD1, which induces a signaling cascade leading to NF-κB activation and the production of inflammatory cytokines. Tri-DAP exhibits a ~3-fold higher ability to activate NF-κB than iE-DAP.

Tri-DAP provided by InvivoGen is chemically synthesized and tested using HEK-Blue™ NOD1.

Note: Tri-DAP is a mixture of L-Ala-γ-D-Glu-D-mDAP and L- Ala-γ-D-Glu-L-mDAP.