Recombinant viral proteins for type I and type II interferon inhibition
InvivoGen offers two powerful tools for investigating interferon signaling pathways:
- B18R, a type I interferon (IFN-α, IFN-β,...) inhibitor
- B8R, a type II interferon (IFN-γ) inhibitor
B18R and B8R are viral decoy receptors encoded by the vaccinia virus, each targeting a distinct interferon pathway. B18R binds and neutralizes type I interferons (e.g., IFN-α/β) across multiple species, preventing antiviral responses and enhancing mRNA transfection efficiency. B8R blocks interferon-gamma (IFN-γ) signaling, suppressing immune activation and enabling studies in immune evasion, cancer immunotherapy, and IFN-γ-related toxicities. Both are powerful tools for dissecting interferon biology and modulating immune responses in vitro.
B18R and B8R are InvitroFit™ grade recombinant proteins (≥ 95% purity), produced in CHO cells to ensure proper glycosylation and structural integrity. These proteins are functionally validated using proprietary cell lines. They are free of endotoxins and other contaminants and provided carrier-free for optimal performance in sensitive applications.
Key features
- Proven efficacy in blocking IFN activity in cellular assays
- Provided carrier-free and His-tagged
- InvitroFit™ grade: each lot is highly pure (≥95%) and functionally tested.
Applications
- Blockade of type I and II IFN signaling in cell-based assays
- Analysis of interferon-mediated immune mechanisms
InvitroFit™
InvitroFit™ is a high-quality standard specifically adapted for in vitro studies of inhibitors. InvitroFit™ products are guaranteed free of bacterial contamination, as confirmed using HEK Blue™ TLR2 and HEK Blue™ TLR4 cellular assays. Each lot is rigorously tested for functional activity using validated (or proprietary) cellular models. This grade ensures reliability and reproducibility for your research applications.
