COVID-19-Related Antibodies

Recombinant mAbs for SARS-CoV-2 Research 

Monoclonal antibodies (mAbs) against SARS-CoV-2 antigens or host pro-inflammatory cytokine receptors are under therapeutic investigation for fighting COVID-19.
InvivoGen offers isotype families of recombinant mAbs related to COVID-19 research.

• Anti-SARS-CoV-2 Spike mAbs: target the SARS-CoV-2 RBD
  — CR3022-derived antibodies
  — H4-derived antibodies
  — B38-derived antibodies
  — REGN-10933 & REGN-10987-derived antibodies
  — LY-CoV555 & LY-CoV016-derived antibodies
   

➔ Check the activity of these antibodies on SARS-CoV2 Spike variants (in-house data)

• Anti-SARS-CoV-2 Nucleocapsid mAb: targets the SARS-CoV-2 Nucleocapsid
  — CR3018-derived antibody
   
• Anti-human ACE2 mAb: targets the SARS-CoV-2 cellular receptor ACE2
  — 1D10 monoclonal antibody
   
• Anti-hIL-6R mAbs: target the human interleukin-6 receptor
  — Tocilizumab-derived antibodies
   

ISOTYPE FAMILIES

These antibodies are available with different immunoglobulin isotypes, either native or engineered. The different isotypes can trigger or hinder mAb effector functions including, complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity or phagocytosis (ADCC or ADCP). Depending on your target and application, InvivoGen offers:
 

• Human isotypes

hIgG1: highly-represented in the serum and a potent inducer of ADCC, ADCP, and CDC
hIgG1NQ: non-glycosylated hIgG1 exhibiting ablated ADCC and ADCP, as well as severely compromised CDC
hIgA: main antibody isotype present in mucosal secretions (i.e. in the respiratory tract) and a moderate inducer of ADCC and ADCP
hIgM: first antibody isotype raised in the immune response and a potent inducer of CDC
 

• Mouse isotypes

mIgG2a & mIgG2b: most potent inducers of ADCC, ADCP, and CDC among murine isotypes
mIgG1e3: effectorless mIgG1 with a D265A point mutation

As a guarantee of quality, our antibody constructs are fully sequenced and their target binding has been validated.

InvivoGen’s products are for research use only, and not for clinical or veterinary use.