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pDRIVE-SV40 / hAlb

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-SV40-hAlb

pDRIVE bearing human SV40 / hAlb promoter - LacZ

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20 µg

pdrive-sv40halb
+-
$554

pDRIVE5SEAP-SV40-hAlb

pDRIVE bearing human SV40 / hAlb promoter - SEAP

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20 µg

pdrive5s-sv40halb
+-
$554

pDRIVE5Lucia-SV40-hAlb

pDRIVE bearing human SV40 / hAlb promoter - Lucia

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20 µg

pdrive5lc-sv40halb
+-
$554

SV40 / hAlb promoter (Liver) in pDRIVE expression plasmid

The albumin gene is transcribed at very high levels in fetal liver and, unlike the adjacent AFP gene, remains active after birth. A small segment of the bovine albumin 5’flanking region, from -170 to +20, is sufficient for promoter activity and specificity [1].

This segment contains the CCAAT box, TATA box and the binding site of HNF1, a liver specific transcription factor.

The albumin promoter is a liver-specific promoter. It can drive the expression of a transgene, such as HSV-tk, specifically in hepatocellular carcinoma cells eliminating the risk of systemic toxicity of GCV [2].

 

References:

1. Power SC. et al. 1994. Isolation and functional analysis of the promoter of the bovine serum albumin gene. Biochem Biophys Res Com 203(3):1447-1456.
2. Kuriyama S. et al. 1997. Tissue-specific expression of HSV-tk gene can induce efficient antitumor effect and protective immunity to wild-type hepatocellular carcinoma. Int J Cancer. 71(3):470-5.

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Specifications

pDRIVE bearing human SV40 / hAlb promoter - LacZ, SEAP or Lucia

Gene Promoter: Alb: Albumin

Specificity: Liver

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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