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pDRIVE-GFAP

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hGFAP

pDRIVE bearing human GFAP promoter - LacZ

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20 µg

pdrive-hgfap
+-
$554

pDRIVE5SEAP-hGFAP

pDRIVE bearing human GFAP promoter - SEAP

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20 µg

pdrive5s-hgfap
+-
$554

pDRIVE5Lucia-hGFAP

pDRIVE bearing human GFAP promoter - Lucia

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20 µg

pdrive5lc-hgfap
+-
$554

pDRIVE-mGFAP

pDRIVE bearing mouse GFAP promoter - LacZ

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20 µg

pdrive-mgfap
+-
$554

pDRIVE5SEAP-mGFAP

pDRIVE bearing mouse GFAP promoter - SEAP

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20 µg

pdrive5s-mgfap
+-
$554

pDRIVE5Lucia-mGFAP

pDRIVE bearing mouse GFAP promoter - Lucia

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20 µg

pdrive5lc-mgfap
+-
$554

pDRIVE-rGFAP

pDRIVE bearing rat GFAP promoter - LacZ

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20 µg

pdrive-rgfap
+-
$554

pDRIVE5SEAP-rGFAP

pDRIVE bearing rat GFAP promoter - SEAP

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20 µg

pdrive5s-rgfap
+-
$554

pDRIVE5Lucia-rGFAP

pDRIVE bearing rat GFAP promoter - Lucia

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20 µg

pdrive5lc-rgfap
+-
$554

GFAP promoter (Astrocytes) in pDRIVE expression plasmid

The glial fibrillary acidic protein (GFAP) is an intermediate filament protein found almost exclusively in astrocytes. It is expressed throughout postnatal life and is upregulated in response to almost any damage to the central nervous system, including Parkinson's disease.

The promoter of the GFAP gene was shown to direct astrocyte-specific transcription in vitro, in vivo [1], and in transgenic mice [2].

The expression of a transgene under the control of the GFAP promoter is regulated in a similar fashion as the endogenous GFAP gene [3].

 

References:

1. Vandier et al. 2000. Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter. Cancer Gene Ther 7:1120-6.
2. Brenner et al. 1994. GFAP promoter directs astrocyte-specific expression in transgenic mice. Neurosci. 14:1030-7.
3. Jakobsson J. et al., 2004. Lesion-dependent regulation of transgene expression in the rat brain using a human glial fibrillary acidic protein-lentiviral vector. Eur J Neurosci. 19(3):761-5.

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Specifications

pDRIVE bearing human GFAP promoter - LacZ, SEAP or Lucia

Gene Promoter: Glial Fibrillary Acidic Protein

Specificity: Astrocytes

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

pDRIVE bearing mouse GFAP promoter - LacZ, SEAP or Lucia

Gene: Glial Fibrillary Acidic Protein

Specificity: Astrocytes

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

pDRIVE bearing rat GFAP promoter - LacZ, SEAP or Lucia

Gene: Glial Fibrillary Acidic Protein

Specificity: Astrocytes

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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