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pDRIVE-ICAM-2

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-ICAM2

pDRIVE bearing human ICAM-2 promoter - LacZ

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20 µg

pdrive-hicam2
+-
$554

pDRIVE5SEAP-ICAM2

pDRIVE bearing human ICAM-2 promoter - SEAP

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20 µg

pdrive5s-hicam2
+-
$554

pDRIVE5Lucia-ICAM2

pDRIVE bearing human ICAM-2 promoter - Lucia

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20 µg

pdrive5lc-hicam2
+-
$554

ICAM-2 promoter (Endothelial cells) in pDRIVE expression plasmid

ICAM-2 is a cell surface adhesion molecule constitutively expressed in vasculature endothelial cells and megakaryocytes.

Endothelial-specific activity of the ICAM-2 promoter resides in a 334 bp fragment in the 5’ flanking region of the gene [1].

The promoter contains no TATA box but four transcription factor binding sites such as Sp1 and GATA motifs, essential for basal and endothelial-specific expression of the ICAM-2 gene.

The ICAM-2 promoter has been used to generate transgenic animals which demonstrated endothelial expression of a transgene [2,3].

 

References:

1. Cowan PJ. et al., 1998. The human ICAM-2 promoter is endothelial cell-specific in vitro and in vivo and contains critical Sp1 and GATA binding sites. J Biol Chem. 273(19):11737-44.
2. Cowan PJ. et al., 1996. Targeting gene expression to endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter. Transplantation. 62(2):155-60.
3. Velasco B. et al.,. 2001. Vascular gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters. Gene Ther. 8(12):897-904.

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Specifications

pDRIVE bearing human ICAM-2 promoter - LacZ, SEAP or Lucia

Gene Promoter: Intracellular Adhesion Molecule 2

Alias: CD102

Specificity: Endothelial cells

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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