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pDRIVE-CD68

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hCD68

pDRIVE bearing human CD68 promoter - LacZ

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20 µg

pdrive-hcd68
+-
$554

pDRIVE5SEAP-hCD68

pDRIVE bearing human CD68 promoter - SEAP

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20 µg

pdrive5s-hcd68
+-
$554

pDRIVE5Lucia-hCD68

pDRIVE bearing human CD68 promoter - Lucia

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20 µg

pdrive5lc-hcd68
+-
$554

pDRIVE-mCD68

pDRIVE bearing mouse CD68 promoter - LacZ

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20 µg

pdrive-mcd68
+-
$554

pDRIVE5SEAP-mCD68

pDRIVE bearing mouse CD68 promoter - SEAP

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20 µg

pdrive5s-mcd68
+-
$554

pDRIVE5Lucia-mCD68

pDRIVE bearing mouse CD68 promoter - Lucia

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20 µg

pdrive5lc-mcd68
+-
$554

CD68 promoter (Macrophages) in pDRIVE expression plasmid

Murine macrosialin and its human homolog CD68 are heavily glycosylated transmembrane proteins expressed specifically in macrophages and macrophage-related cells.

The CD68 gene promoter directs macrophage-specific expression. Although the promoter lacks a classical TATA box, it contains other protein binding sites consistent with preferential monocyte/macrophage gene expression1.

CD68 promoter has been used to achieve constitutive expression of IL-10 specifically in macrophages [2].

 

References:

1. Jiang Z. et al. 1998. Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein. Genomics 50(2):199-205.
2. Lang R.et al. 2002. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol. 168(7):3402-11.

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Specifications

pDRIVE bearing human CD68 promoter - LacZ, SEAP or Lucia

Gene Promoter: Homolog of Macrosialin

Specificity: Macrophages

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

pDRIVE bearing mouse CD68 promoter - LacZ, SEAP or Lucia

Gene: Homolog of Macrosialin

Specificity: Macrophages

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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