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pDRIVE-Fibronectin

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hFibronectin

pDRIVE bearing human Fibronectin promoter - LacZ

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20 µg

pdrive-hfn
+-
$554

pDRIVE5SEAP-hFibronectin

pDRIVE bearing human Fibronectin promoter - SEAP

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20 µg

pdrive5s-hfn
+-
$554

pDRIVE5Lucia-hFibronectin

pDRIVE bearing human Fibronectin promoter - Lucia

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20 µg

pdrive5lc-hfn
+-
$554

Fibronectin promoter (Differentiating cells, healing tissues) in pDRIVE expression plasmid

Fibronectin (FN) plays an important role in organizing the extracellular matrix and facilitates cell adhesion, migration, wound healing and tumor metastasis.

FN expression is generally low in undifferentiated cells and most adult tissues. However, synthesis is drastically increased after differentiation and during wound healing.

Expression of FN is regulated at the transcriptional level in a cell-specific manner by a variety of transcription factors, growth factors and hormones.

The FN promoter contains a TATA box, a CAAT sequence, a SP-1 binding site, a cAMP-responsive element [1] and two EGR-1 binding sites.

The FN promoter can be activated in vitro in cell lines that normally do not express FN after induction of differentiation [2].

 

References:

1. Dean DC. et al. 1987. Cloning and analysis of the promoter region of the human fibronectin gene. Proc Natl Acad Sci USA 84(7): 1876-80. 2. Suzuki M. et al. 1998. Induction of Sp1 in differentiating human embryonal carcinoma cells triggers transcription of the fibronectin gene. Mol Cell Biol. 18(5):3010-20.

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Specifications

pDRIVE bearing human Fibronectin promoter - LacZ, SEAP or Lucia

Gene Promoter: Fibronectin

Specificity: Differentiating cells, healing tissues

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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