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pDRIVE-CD14

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hCD14

pDRIVE bearing human CD14 promoter - LacZ

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20 µg

pdrive-hcd14
+-
$554

pDRIVE5SEAP-hCD14

pDRIVE bearing human CD14 promoter - SEAP

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20 µg

pdrive5s-hcd14
+-
$554

pDRIVE5Lucia-hCD14

pDRIVE bearing human CD14 promoter - Lucia

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20 µg

pdrive5lc-hcd14
+-
$554

CD14 promoter (Monocytic cells) in pDRIVE expression plasmid

CD14 is a receptor for bacterial lipopolysaccharide expressed on the surface of myeloid-derived cells, and is strongly upregulated during monocytic cell differentiation.

Monocyte-specific expression of CD14 is regulated at the transcriptional level.

The CD14 promoter contains a C/EBP [1] and Sp1 [2] site that are critical for tissue-specific regulation of CD14 gene expression. 

 

References:

1. Pan Z. et al. 1999. CCAAT/enhancer-binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development. J Biol Chem 274(33):23242-8.
2. Park S. et al. 2002. Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter. Mol Immunol 39(1-2):25.

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Specifications

pDRIVE bearing human CD14 promoter - LacZ, SEAP or Lucia

Gene Promoter: Monocyte Receptor for Bacterial LPS

Specificity: Monocytic cells

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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Details

pDRIVE map

pDRIVE5-SEAP map

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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