pDRIVE-Endoglin Unit size Cat. code Docs Qty Price
pDRIVE bearing human Endoglin promoter - LacZ
20 µg
pDRIVE5SEAP-Endoglin Unit size Cat. code Docs Qty Price
pDRIVE bearing human Endoglin promoter - SEAP
20 µg
pDRIVE5Lucia-Endoglin Unit size Cat. code Docs Qty Price
pDRIVE bearing human Endoglin promoter - Lucia
20 µg

Endoglin promoter (Endothelial cells) in pDRIVE expression plasmid

Endoglin (CD105) is a transforming growth factor-beta (TGF-β) coreceptor expressed mainly on endothelial cells and preferentially in the neovasculature associated with hypoxia such as ischemic tissues and tumors.

The endoglin promoter lacks consensus TATA and CAAT boxes but contains Sp1, NF-κB and TGF-β binding sites [1]. These sites are located in a -400/+341 fragment upstream of the endoglin gene which is sufficient to confer endothelial specificity.

Regulation of endoglin occurs at the transcriptional level; basal endoglin transcription is highly dependent on Sp1 and is stimulated by TGF-β and hypoxia [2].

The endoglin promoter has been used to target gene expression to the vasculature in transgenic animals [3].



1. Rius C. et al., 1998. Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. Blood. 92(12):4677-90.
2. Sanchez-Elsner T. et al., 2002. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem. 277(46):43799-808.
3. Cowan PJ. et al., 2003. Targeting gene expression to endothelium in transgenic animals: a comparison of the human ICAM-2, PECAM-1 and endoglin promoters. Xenotransplantation. 10(3):223-31.

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pDRIVE bearing human Endoglin promoter - LacZ, SEAP or Lucia

Gene Promoter: Endoglin

Specificity: Endothelial cells

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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pDRIVE map


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