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TLR04

pUNO1-bTLR04 Unit size Cat. code Docs Qty Price
pUNO1 bearing the bovine TLR4 gene
20 µg
puno1-btlr4
+-
$384.00
pUNO1-hTLR04a Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR4 gene, isoform_1
20 µg
puno1-htlr4a
+-
$384.00
pUNO3-hTLR04a Unit size Cat. code Docs Qty Price
pUNO3 bearing the human TLR4 gene, isoform_1
20 µg
puno3-htlr4a
+-
$384.00
pUNO1-mTLR04 Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR4 gene
20 µg
puno1-mtlr4
+-
$384.00
pUNO1-pTLR04 Unit size Cat. code Docs Qty Price
pUNO1 bearing the pig TLR4 gene
20 µg
puno1-ptlr4
+-
$384.00

Expression-ready ORF Clones

Alias : TLR4, CD284

Toll Like Receptor 4

TLR4, the first human TLR identified, is the receptor for Gram-negative lipopolysaccharide (LPS). The TLR4 gene was shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS) [1]. However, TLR4 alone is not sufficient to confer LPS responsiveness. TLR4 requires MD-2, a secreted molecule, to functionally interact with LPS [2]. Furthermore, a third protein, called CD14, was shown to participate in LPS signaling, leading to NF-κB translocation. This signaling is mediated through the adapter protein MyD88 but also through a MyD88-independent pathway that involves the (TIR) domain-containing adapter protein (TIRAP) [3].

 

1. Poltorak et al. (1998). Science, 282(5396):2085-8.
2. Shimazu et al. (1999). J Exp Med, 189(11):1777-82
3. Horng et al. (2001). Nat Immunol, 2(9):835-41

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Specifications

Bovine TLR4 (pUNO1-bTLR04)

Genbank : NM_174198.6
ORF size : 2526 bp
Subclone : AgeI - NheI

Human TLR4 isoform 1 (pUNO1-hTLR04a)

ORF size : 2520 bp
Subclone : BspHI - NheI

Human TLR4 isoform 1 (pUNO3-hTLR04a)

ORF size : 2520 bp
Subclone : BspHI - NheI

Mouse TLR4 (pUNO1-mTLR04)

Genbank : JX878358.1
ORF size : 2508 bp
Subclone : BspHI - NheI

Pig TLR4 (pUNO1-pTLR04)

ORF size : 2526 bp
Subclone : AgeI - NheI

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Contents

pUNO1-bTLR04, pUNO1-hTLR04a, pUNO1-mTLR04, pUNO1-pTLR04:
- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml

pUNO3-hTLR04a:
- 20 µg of lyophilized DNA.
- 1 ml Hygromycin B Gold (hygromycin) at 100 mg/ml

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Citations

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