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TLR4 Agonists

Toll-like receptor 4 (TLR4) is the receptor for Gram-negative lipopolysaccharide (LPS) and lipid A, its toxic moiety.

InvivoGen supplies LPS from various bacteria and monophosphoryl lipid A (MPLA purified from S. minnesota R595 or synthetic MPLA from E. coli).

MPLA VacciGrade™ (preclinical grade: guaranteed sterile) for use as a vaccine adjuvant is also available.

InvivoGen provides LPS with two grades of purity:

  • Standard LPS:

LPS-EB and LPS-EK are standard preparations of lipopolysaccharide. They are extracted by a phenol-water mixture. LPS-EB and LPS-EK contain other bacterial components, such as lipopeptides, and therefore stimulate both TLR4 and TLR2.

  • Ultra-pure LPS: 

Ultrapure LPS-EB (E. coli 0111:B4), LPS-EK (E. coli K12) and LPS-SM (S. minnesota Re type) are extracted by successive enzymatic hydrolysis steps and purified by the phenol-TEA-DOC extraction protocol.

The functionality of these TLR ligands are validated using HEK-Blue™ TLR4 Cells.

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