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TLR06

pUNO1-bTLR06 Unit size Cat. code Docs Qty Price
pUNO1 bearing the bovine TLR6 gene
20 µg
puno1-btlr6
+-
$384.00
pUNO1-hTLR06 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR6 gene
20 µg
puno1-htlr6
+-
$384.00
pUNO3-hTLR06 Unit size Cat. code Docs Qty Price
pUNO3 bearing the human TLR6 gene
20 µg
puno3-htlr6
+-
$384.00
pUNO1-mTLR06 Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR6 gene
20 µg
puno1-mtlr6
+-
$384.00
pUNO1-pTLR06 Unit size Cat. code Docs Qty Price
pUNO1 bearing the pig TLR6 gene
20 µg
puno1-ptlr6
+-
$384.00

Expression-ready ORF Clones

Alias : TLR6, CD286

Toll Like Receptor 6

TLR6 is expressed in spleen and BPL and, similarly to TLR1, acts as a co-receptor. Studies with dominant negative receptors have shown that TLR6 cooperates with TLR2 to recognize peptidoglycan and the yeast cell wall particle, zymosan [1]. Furthermore, TLR6- and TLR2-deficient mice were reported to be hyporesponsive to mycoplasma macrophage-activating lipopeptide-2 kD (MALP-2), a diacylated lipoprotein, suggesting that TLR2 and TLR6 coordinate the response to this ligand. By contrast, TLR2 is able to recognize bacterial lipoproteins triacylated at the N-terminus cysteine residue [2]. Thus TLR6 appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria.

 

1. Ozinsky A. et al. (2000). Proc Natl Acad Sci U S A 97(25):13766-71.
2. Takeuchi O. et al. (2001). Int Immunol, 13(7):933-40.

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Specifications

Bovine TLR6 (pUNO1-bTLR06)

ORF size : 2391 bp
Subclone : AgeI - NheI

Human TLR6 (pUNO1-hTLR06)

Genbank : NM_006068.4
ORF size : 2391 bp
Subclone : AgeI - NheI

Human TLR6 (pUNO3-hTLR06)

ORF size : 2391 bp
Subclone : AgeI - NheI

Mouse TLR6 (pUNO1-mTLR06)

Genbank : NM_011604.3
ORF size : 2421 bp
Subclone : NcoI - NheI

Pig TLR6 (pUNO1-pTLR06)

Genbank : AB210286.1
ORF size : 2391 bp
Subclone : AgeI - NheI

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Contents pUNO-TLR

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

 

pUNO1 plamids:

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.
Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.
Avoid repeated freeze-thaw cycles.

 

pUNO3 plasmid:

Hygromycin B is a hazardous compound. Avoid contact with skin and eyes.
Store Hygromycin B Gold at 4°C or -20˚C.
Avoid repeated freeze-thaw cycles.

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