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TLR01

pUNO1-bTLR01 Unit size Cat. code Docs Qty Price
pUNO1 bearing the bovine TLR1 gene
20 µg
puno1-btlr1
+-
$384.00
pUNO1-hTLR01 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR1 gene
20 µg
puno1-htlr1
+-
$384.00
pUNO3-hTLR01 Unit size Cat. code Docs Qty Price
pUNO3 bearing the human TLR1 gene
20 µg
puno3-htlr1
+-
$384.00
pUNO1-mTLR01 Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR1 gene
20 µg
puno1-mtlr1
+-
$384.00
pUNO1-pTLR01 Unit size Cat. code Docs Qty Price
pUNO1 bearing the pig TLR1 gene
20 µg
puno1-ptlr1
+-
$384.00

Expression-ready ORF Clones

Alias : TLR1, CD281

Toll Like Receptor 1

TLR1 (Toll-Like Receptor 1), the first member of the toll-like receptor family, was identified by the presence of a domain homology found in both Drosophila Toll and human interleukin-1 receptors. 

TLR1 is expressed at higher levels in the spleen and peripheral blood cells [1]. No direct ligands have been identified so far for TLR1, and its function remains unclear. 

TLR1 seems to act as a coreceptor. TLR1 was shown to associate with TLR2 in response to triacylated lipopeptides [2], but not diacylated lipopeptides [3].

These observations suggest that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration.

 

References:

1. Zarember KA. & PJ. Godowski (2002). J Immunol, 168(2):554-61.
2. Takeuchi O. et al. (2002). J Immunol, 169(1):10-4.
3. Takeuchi O.et al. (2001). Int Immunol, 13(7):933-40.

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Specifications

Bovine TLR1 (pUNO1-bTLR01)

Genbank : FJ147090
ORF size : 2379 bp
Subclone : BspHI - NheI

Human TLR1 (pUNO1-hTLR01)

Genbank : NM_003263.3
ORF size : 2361 bp
Subclone : AgeI - NheI

Human TLR1 (pUNO3-hTLR01)

ORF size : 2358 bp
Subclone : AgeI - NheI

Mouse TLR1 (pUNO1-mTLR01)

Genbank : NM_030682.2
ORF size : 2388 bp
Subclone : BspHI - NheI

Pig TLR1 (pUNO1-pTLR01)

Genbank : AB210286
ORF size : 2391 bp
Subclone : BspHI - NheI

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Contents pUNO-TLR

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

 

pUNO1 plamids:

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.
Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.
Avoid repeated freeze-thaw cycles.

 

pUNO3 plasmid:

Hygromycin B is a hazardous compound. Avoid contact with skin and eyes.
Store Hygromycin B Gold at 4°C or -20˚C.
Avoid repeated freeze-thaw cycles.

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