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TLR07-DN

pUNO1-hTLR07-DN Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR7-DN gene
20 µg
puno1-htlr7-dn
+-
$406.00
pUNO1-mTLR07-DN Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR7-DN gene
20 µg
puno1-mtlr7-dn
+-
$406.00
pUNO1-hTLR07-DN-HA Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR7-DN gene, with HA-tag
20 µg
puno1ha-htlr7-dn
+-
$406.00
pUNO1-mTLR07-DN-HA3x Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR7-DN gene, with HA-tag
20 µg
puno1ha-mtlr7-dn
+-
$406.00

Expression-ready ORF Clones

Alias : TLR7, CD287

TLR7-DN (ΔTIR) : Dominant Negative TIR-less TLR7 gene

 

TLR7 is phylogenetically close to TLR8 and TLR9 and has a higher molecular weight when compared with hTLR1-6, largely as a result of a longer ectodomain [1]. TLR7 recognizes single stranded RNAs and small synthetic molecules such as imidazoquinolines and nucleoside analogs [2,3].
TLR7-DN is a TIR-less form of the TLR7 gene generated by deleting the TIR domain (480 bp). This truncated TLR7 gene is still able to recognize its ligands but is unable to induce the signaling cascade.

 

1. Chuang TH. & RJ. Ulevitch (2000). Eur Cytokine Netw, 11(3):372-8.
2. Hemmi H. et al (2002). Nat Immunol, 3(2):196-200.
3. Lee J et al. (2003). Proc Natl Acad Sci U S A, 100(11):6646-6651

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Specifications

Human TLR7-DN (pUNO1-hTLR07-DN)

ORF size : 2670 bp
Subclone : AgeI - NheI

Mouse TLR7-DN (pUNO1-mTLR07-DN)

ORF size : 2673 bp
Subclone : AgeI - NheI

Human TLR7-DN-HA (pUNO1-hTLR07-DN-HA)

Subclone : AgeI - NheI

Mouse TLR7-DN-HA (pUNO1-mTLR07-DN-HA)

ORF size : 2766 bp
Subclone : AgeI - NheI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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