Invivogen
Menu

TLR01-DN

pUNO1-hTLR01-DN Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR1-DN gene
20 µg
puno1-htlr1-dn
+-
$406.00
pUNO1-mTLR01-DN Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR1-DN gene
20 µg
puno1-mtlr1-dn
+-
$406.00
pUNO1-hTLR01-DN-HA Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR1-DN gene, with HA-tag
20 µg
puno1ha-htlr1-dn
+-
$406.00
pUNO1-mTLR01-DN-HA Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR1-DN gene, with HA-tag
20 µg
puno1ha-mtlr1-dn
+-
$406.00

Expression-ready ORF Clones

Alias : TLR1, CD281

TLR1-DN (ΔTIR) : Dominant Negative TIR-less TLR1 gene

 

TLR1, the first member of the toll-like receptor family, was identified by the presence of a domain homology found in both Drosophila Toll and human interleukin-1 receptors.
TLR1 is expressed at higher levels in the spleen and peripheral blood cells [1]. No direct ligands have been identified so far for TLR1, and its function remains unclear. TLR1 seems to act as a coreceptor. TLR1 was shown to associate with TLR2 in response to triacylated lipopeptides [2], but not diacylated lipopeptides [3]. These observations suggest that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration. TLR1-DN is a TIR-less form of the TLR1 gene generated by deleting the TIR domain (453 bp).

1. Zarember KA. & PJ. Godowski (2002). J Immunol, 168(2):554-61.
2. Takeuchi O. et al. (2002). J Immunol, 169(1):10-4.
3. Takeuchi O.et al. (2001). Int Immunol, 13(7):933-40.

Back to the top

Specifications

Human TLR1-DN (pUNO1-hTLR01-DN)

ORF size : 1908 bp
Subclone : AgeI - NheI

Mouse TLR1-DN (pUNO1-mTLR01-DN)

ORF size : 1917 bp
Subclone : AgeI - NheI

Human TLR1-DN-HA (pUNO1-hTLR01-DN-HA)

ORF size : 2001 bp
Subclone : AgeI - NheI

Mouse TLR1-DN-HA (pUNO1-mTLR01-DN-HA)

Subclone : AgeI - NheI

Back to the top

Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

Back to the top
Customer Service
& Technical Support
Shopping cart is empty