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pDUO-TLR1/TLR2

pDUO-hTLR1/TLR2 Unit size Cat. code Docs Qty Price
pDUO bearing human TLR1/TLR2 Gene
20 µg
pduo-htlr1tlr2
+-
$464.00
pDUO-mTLR1/TLR2 Unit size Cat. code Docs Qty Price
pDUO bearing mouse TLR1/TLR2 Gene
20 µg
pduo-mtlr1tlr2
+-
$464.00

pDUO-TLR1/TLR2 is an expression vector designed to co-express TLR1 and TLR2 genes known to interact with each other : human TLR1 (2358 bp) and  human TLR2 (2352 bp) or mouse TLR1 (2388 bp) and  mouse TLR2 (2355 bp).

The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

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Specifications

pDUO plasmid with human TLR1 and human TLR2 genes.
Name: TLR1 / TLR2
Species:
Human
Backbone: pDUO
Selection: Blasticidin

pDUO plasmid with murine TLR1 and murine TLR2 genes.
Name: TLR1 / TLR2
Species:
Mouse
Backbone: pDUO
Selection: Blasticidin

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Contents

- 20 µg of lyophilized DNA
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)

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Description

TLR1, the first member of the Toll-Like Receptor family was identified by the presence of a domain homology found in both Drosophila Toll and human IL-1 receptors. So far, no direct ligands for TLR1 have been identified however it seems to act as a coreceptor. TLR1 has been shown to associate with TLR2 in response to triacylated lipopeptides [1], but not diacylated lipopeptides[2]. These observations suggest that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration.

1. Takeuchi O. et al., 2002. J Immunol, 169(1):10-14.
2. Takeuchi O. et al., 2001. Int Immunol, 13(7): 933-40.

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Details

pDUO backbone

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Citations

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