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TLR03

pUNO1-hTLR03 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR3 gene
20 µg
puno1-htlr3
+-
$384.00
pUNO3-hTLR03 Unit size Cat. code Docs Qty Price
pUNO3 bearing the human TLR3 gene
20 µg
puno3-htlr3
+-
$384.00
pUNO1-mTLR03 Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR3 gene
20 µg
puno1-mtlr3
+-
$384.00
pUNO1-pTLR03 Unit size Cat. code Docs Qty Price
pUNO1 bearing the pig TLR3 gene
20 µg
puno1-ptlr3
+-
$384.00

Expression-ready ORF Clones

Alias : TLR3, CD283

Toll Like Receptor 3

TLR3 recognizes double-stranded RNA (dsRNA), a molecular pattern associated with viral infection. 

Stimulation with polyinosine-polycytidylic acid (poly(I:C)), a synthetic analog of dsRNA, was shown to induce hyporesponsiveness in TLR3-deficient mice and marked responsiveness only in 293 cells expressing TLR3 [1], suggesting a specific recognition to poly(I:C) by TLR3. 

Furthermore, TLR3 signaling is not elicited by either single-stranded RNA (ssRNA) or dsDNA [2].

TLR3 activation induces cytokine production through a signaling pathway dependent on MyD88. Moreover, poly(I:C) can induce activation of NF-κB and mitogen-activated protein kinases independently of MyD88, and cause dendritic cells to mature [1].

 

References

1. Alexopoulou L. et al. (2001). Nature 413(6857):732-8.
2. Matsumoto M. et al. (2002). Biochem Biophys Res Commun. 293(5):1364-9.

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Specifications

Human TLR3 (pUNO1-hTLR03)

ORF size : 2715 bp
Subclone : AgeI - NheI

Human TLR3 (pUNO3-hTLR03)

ORF size : 2712 bp
Subclone : AgeI - NheI

Mouse TLR3 (pUNO1-mTLR03)

Genbank : NM_126166.4
ORF size : 2718 bp
Subclone : BspHI - NheI

Pig TLR3 (pUNO1-pTLR03)

Genbank : NM_001097444.1
ORF size : 2718 bp
Subclone : AgeI - NheI

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Contents

pUNO1-hTLR3, pUNO1-mTLR3, pUNO1-pTLR03:

pUNO3-hTLR03:

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Citations

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