pDRIVE-COX-2
| pDRIVE-hCOX2 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing human COX-2 promoter - LacZ |
20 µg |
pdrive-hcox2 |
| pDRIVE5SEAP-hCOX2 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing human COX-2 promoter - SEAP |
20 µg |
pdrive5s-hcox2 |
| pDRIVE5Lucia-hCOX2 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing human COX-2 promoter - Lucia |
20 µg |
pdrive5lc-hcox2 |
| pDRIVE-mCOX2 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing mouse COX-2 promoter - LacZ |
20 µg |
pdrive-mcox2 |
| pDRIVE5SEAP-mCOX2 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing mouse COX-2 promoter - SEAP |
20 µg |
pdrive5s-mcox2 |
| pDRIVE5Lucia-mCOX2 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing mouse COX-2 promoter - Lucia |
20 µg |
pdrive5lc-mcox2 |
COX-2 promoter in pDRIVE expression plasmid
COX-2 is an inducible isoform of cyclooxygenase. The expression of COX-2 is undetectable under physiological conditions but up-regulated in many malignant tumors.
COX-2, which is a PKC-dependent gene, is important for the genesis of cancer. COX-2 promoter contains a cAMP response element and sites for AP-2 and NF-κB that are both PKC-responsive cis-elements.
COX-2 promoter has been used to target gene expression in pancreatic [1], gastrointestinal [2] and ovarian cancers. Similar levels of expression of luciferase and HSVtk genes were obtained with COX-2 and CMV promoters.
References:
1. Wesseling JG et al. 2001. Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. Cancer Gene Ther 8(12):990-6.
2. Yamamoto M et al. 2001. Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy ofgastrointestinal cancers. Mol Ther. 3(3):385-94.
Specifications
pDRIVE bearing human COX-2 promoter - LacZ, SEAP or Lucia
Gene Promoter: Cyclo-oxygenase 2 isoform
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
pDRIVE bearing mouse COX-2 promoter - LacZ, SEAP or Lucia
Gene: Cyclo-oxygenase 2 isoform
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
pDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
