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pDRIVE-TRP1

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-mTRP

pDRIVE bearing mouse TRP1 promoter - LacZ

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20 µg

pdrive-mtrp
+-
$554

pDRIVE5SEAP-mTRP

pDRIVE bearing mouse TRP1 promoter - SEAP

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20 µg

pdrive5s-mtrp
+-
$554

pDRIVE5Lucia-mTRP

pDRIVE bearing mouse TRP1 promoter - Lucia

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20 µg

pdrive5lc-mtrp
+-
$554

Tyrosinase-related protein 1 (TRP1) promoter in pDRIVE expression plasmid

The TRP1 gene encodes the tyrosinase-related protein 1, an enzyme involved in the process that converts tyrosinase to melanin pigments.

Expression of TRP1 is restricted to melanocytes and melanoma cells partly as a consequence of transcriptional regulation of its mRNA.

The TRP1 promoter shares with the tyrosinase promoter an 11-bp motif termed the M box located upstream of the TATA box. This M box plays a key role in the regulation of the TRP1 expression by cyclic AMP (cAMP) [1].

Tissue-specific expression of transgenes, such as the IL-2 and HSV1-tk genes, driven by the TRP1 promoter has been demonstrated in murine model systems, achieving marked antitumor effects [2].

 

References:

1. Bertolotto C. et al. 1996. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia Mol Cell Biol. 18(2):694-702.
2. Hart IR. 1996. Tissue-specific promoters in targeting systemically delivered gene therapy. Semin Oncol. 23(1):154-8.

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Specifications

pDRIVE bearing mouse TRP1 promoter - LacZ, SEAP or Lucia
Gene Promoter: Tyrosinase Related Protein
Specificity: Melanocytes & melanoma
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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