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pDRIVE-HE4

pDRIVE-hHE4 Unit size Cat. code Docs Qty Price
pDRIVE bearing human HE4 promoter - LacZ
20 µg
pdrive-hhe4
+-
$433.00
pDRIVE5SEAP-hHE4 Unit size Cat. code Docs Qty Price
pDRIVE bearing human HE4 promoter - SEAP
20 µg
pdrive5s-hhe4
+-
$433.00
pDRIVE5Lucia-hHE4 Unit size Cat. code Docs Qty Price
pDRIVE bearing human HE4 promoter - Lucia
20 µg
pdrive5lc-hhe4
+-
$433.00

pDRIVE bearing human HE4 promoter - LacZ, SEAP or Lucia
Gene Promoter: Human Epididymis Protein 4
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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Contents

- Provided as 20 µg lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar).

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Description

The human epididymis protein 4 (HE4), a member of the whey-acidic protein family, is frequently overexpressed in ovarian cancer cells. Upregulation of whey-acidic proteins in cancer appears to be due to a transcriptional event. A 652 bp fragment of the HE4 promoter, from -530 to +122 (relative to the ATG start site of HE4), is capable of restricting the expression of a transgene to ovarian tumor cells. The HE4-652 promoter contains a cAMP inducible element and seven Ap1 sites. Several hormonal responsive elements and inflammatory responsive elements are found within the promoter that may contribute to the high expression of HE4 in ovarian cancer.

1. Berry NB. et al., 2004. Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter. Gynecol Oncol. 92(3):896-904.

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Details

pDRIVE map

pDRIVE5-SEAP map

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