pDRIVE-hHE4
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Cat.code:
pdrive-hhe4
- Documents
ABOUT
Human epididymis protein 4 (HE4) promoter in pDRIVE expression plasmid
The human epididymis protein 4 (HE4), a member of the whey-acidic protein family, is frequently overexpressed in ovarian cancer cells. The upregulation of whey-acidic proteins in cancer appears to be due to a transcriptional event. A 652 bp fragment of the HE4 promoter, from -530 to +122 (relative to the ATG start site of HE4), is capable of restricting the expression of a transgene to ovarian tumor cells. The HE4-652 promoter contains a cAMP inducible element and seven Ap1 sites. Several hormonal responsive elements and inflammatory responsive elements are found within the promoter that may contribute to the high expression of HE4 in ovarian cancer.
References:
1. Berry NB. et al., 2004. Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter. Gynecol Oncol. 92(3):896-904.
All products are for internal research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
in vitro or in vivo transfection
Tumor
in vitro transfection
Plasmid construct has been confirmed by restriction analysis and full-length ORF sequencing.
CONTENTS
Contents
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Product:pDRIVE-hHE4
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Cat code:pdrive-hhe4
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Quantity:20 µg
1 ml of Zeocin® (100 mg/ml)
Shipping & Storage
- Shipping method: Room temperature
- -20°C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Plasmid Map and Sequence
Safety Data Sheet
Certificate of analysis
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