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pDRIVE-E2F-1

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hE2F1

pDRIVE bearing human E2F-1 promoter - LacZ

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20 µg

pdrive-he2f1
+-
$554

pDRIVE5SEAP-hE2F1

pDRIVE bearing human E2F-1 promoter - SEAP

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20 µg

pdrive5s-he2f1
+-
$554

pDRIVE5Lucia-hE2F1

pDRIVE bearing human E2F-1 promoter - Lucia

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20 µg

pdrive5lc-he2f1
+-
$554

E2F promoter in pDRIVE expression plasmid

E2F transcription factors are critical regulators of cell growth and are often overexpressed in cancer cells because of the frequent aberrations in the pRb/E2F/p16(INK4a) pathway.

E2F-1 is a transcription factor that activates its own transcription and that of other genes involved in the G(1) to S transition phase of the cell cycle.

The E2F-1 promoter was used in adenovirus to drive the expression of the E1A adenoviral gene and induced selective killing in a variety of tumor cell lines [1].

 

References:

1. Tsukuda K. et al. 2002. An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell. Cancer Res 62(12):3438-47.

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Specifications

pDRIVE bearing human E2F-1 promoter - LacZ, SEAP or Lucia
Gene Promoter: E2F1 Transcription factor 1
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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