pDRIVE-E2F-1
| pDRIVE-hE2F1 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing human E2F-1 promoter - LacZ |
20 µg |
pdrive-he2f1 |
| pDRIVE5SEAP-hE2F1 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing human E2F-1 promoter - SEAP |
20 µg |
pdrive5s-he2f1 |
| pDRIVE5Lucia-hE2F1 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pDRIVE bearing human E2F-1 promoter - Lucia |
20 µg |
pdrive5lc-he2f1 |
pDRIVE bearing human E2F-1 promoter - LacZ, SEAP or Lucia
Gene Promoter: E2F1 Transcription factor 1
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin
Contents
- Provided as 20 µg lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar).
Description
E2F transcription factors are critical regulators of cell growth and are often overexpressed in cancer cells because of the frequent aberrations in the pRb/E2F/p16(INK4a) pathway. E2F-1 is a transcription factor that activates its own transcription and that of other genes involved in the G(1) to S transition phase of the cell cycle. The E2F-1 promoter was used in an adenovirus to drive the expression of the E1A adenoviral gene and induced selective killing in a variety of tumor cell lines [1].
1. Tsukuda K. et al. 2002. An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell. Cancer Res 62(12):3438-47.
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