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pDRIVE-MUC1

pDRIVE-hMUC1 Unit size Cat. code Docs Qty Price
pDRIVE bearing human MUC1 promoter - LacZ
20 µg
pdrive-hmuc1
+-
$433.00
pDRIVE5SEAP-hMUC1 Unit size Cat. code Docs Qty Price
pDRIVE bearing human MUC1 promoter - SEAP
20 µg
pdrive5s-hmuc1
+-
$433.00
pDRIVE5Lucia-hMUC1 Unit size Cat. code Docs Qty Price
pDRIVE bearing human MUC1 promoter - Lucia
20 µg
pdrive5lc-hmuc1
+-
$433.00

pDRIVE bearing human MUC1 promoter - LacZ, SEAP or Lucia
Gene Promoter: Mucin-like glycoprotein (Breast Carcinoma-associated Antigen)
Alias: DF3
Specificity: Carcinoma cells
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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Contents

- Provided as 20 µg lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar).

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Description

The human MUC1 (DF3) gene encodes a high molecular mass glycoprotein that is aberrantly overexpressed in most human carcinomas, including 80% of breast cancers. Overexpression of the MUC1 gene in human breast cancer cells is regulated at the transcriptional level. Cloning and characterization of the 5' flanking region of the MUC1 gene has shown that expression of the gene is regulated mainly by sequences between positions -598 bp and -485 bp upstream from the transcription start site. The MUC1 promoter has been used in the context of replication-defective adenoviruses to selectively express therapeutic genes, including herpes simplex virus thymidine kinase (HSV-tk) and the BAX proapoptotic gene in MUC1-positive human
carcinoma cells [1, 2].

1. Chen L. et al. 1995. Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter. J. Clin. Invest. 96:2775-2782.
2. Tai YT. et al. 1999. In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene. Cancer Res. 59(9):2121-6.

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Details

pDRIVE map

pDRIVE5-SEAP map

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Citations

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