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pDRIVE-CCKAR

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hCCKAR

pDRIVE bearing human CCKAR promoter - LacZ

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20 µg

pdrive-hcckar
+-
$554

pDRIVE5SEAP-hCCKAR

pDRIVE bearing human CCKAR promoter - SEAP

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20 µg

pdrive5s-hcckar
+-
$554

pDRIVE5Lucia-hCCKAR

pDRIVE bearing human CCKAR promoter - Lucia

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20 µg

pdrive5lc-hcckar
+-
$554

Cholecystokinin (CCK) in pDRIVE expression plasmid

Cholecystokinin (CCK) is a gut peptide hormone known to stimulate postprandial gallbladder contraction and pancreatic enzyme secretion. CCK plays also an important role in pancreatic carcinogenesis. The CCK-A receptor (CCKAR) is predominantly expressed in human pancreatic cancer [1]. A 0.7 kb fragment of the CCKAR promoter was reported to drive the expression of the luciferase gene selectively in pancreatic cancer cells and in not normal cells [2]. This fragment lacks a typical TATA box but contains two GC-box motifs [3].

 

References:

1. Moonka R. et al., 1999. Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer. J Gastrointest Surg. 3(2):134-40.
2. Li Z. et al., 2005. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 236(1):58-63.
3. Takata Y, et al., 2002. Promoter analysis of human cholecystokinin type-A receptor gene. J Gastroenterol. 37(10):815-20.

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Specifications

pDRIVE bearing human CCKAR promoter - LacZ, SEAP or Lucia
Gene Promoter:
Specificity: Pancreatic cancer
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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Details

pDRIVE map

pDRIVE5-SEAP map

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