pDRIVE-CCKAR
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pDRIVE-hCCKAR pDRIVE bearing human CCKAR promoter - LacZ |
Show product |
20 µg |
pdrive-hcckar
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pDRIVE5SEAP-hCCKAR pDRIVE bearing human CCKAR promoter - SEAP |
Show product |
20 µg |
pdrive5s-hcckar
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pDRIVE5Lucia-hCCKAR pDRIVE bearing human CCKAR promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hcckar
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Cholecystokinin (CCK) in pDRIVE expression plasmid
Cholecystokinin (CCK) is a gut peptide hormone known to stimulate postprandial gallbladder contraction and pancreatic enzyme secretion. CCK plays also an important role in pancreatic carcinogenesis. The CCK-A receptor (CCKAR) is predominantly expressed in human pancreatic cancer [1]. A 0.7 kb fragment of the CCKAR promoter was reported to drive the expression of the luciferase gene selectively in pancreatic cancer cells and in not normal cells [2]. This fragment lacks a typical TATA box but contains two GC-box motifs [3].
References:
1. Moonka R. et al., 1999. Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer. J Gastrointest Surg. 3(2):134-40.
2. Li Z. et al., 2005. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 236(1):58-63.
3. Takata Y, et al., 2002. Promoter analysis of human cholecystokinin type-A receptor gene. J Gastroenterol. 37(10):815-20.
Specifications
pDRIVE bearing human CCKAR promoter - LacZ, SEAP or Lucia
Gene Promoter:
Specificity: Pancreatic cancer
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
pDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
