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pDRIVE-CXCR4

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hCXCR4

pDRIVE bearing human CXCR4 promoter - LacZ

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20 µg

pdrive-hcxcr4
+-
$554

pDRIVE5SEAP-hCXCR4

pDRIVE bearing human CXCR4 promoter - SEAP

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20 µg

pdrive5s-hcxcr4
+-
$554

pDRIVE5Lucia-hCXCR4

pDRIVE bearing human CXCR4 promoter - Lucia

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20 µg

pdrive5lc-hcxcr4
+-
$554
  • About
  • Specifications
  • pDRIVE contents
  • Details

CXCR4 promoter in pDRIVE expression plasmid

CXCR4 is the receptor for the chemokine SDF1 and a coreceptor for HIV-1 entry. The expression of CXCR4 is upregulated in many types of cancers but low in the liver and other major organs. The CXCR4 promoter contains a TATAbox, a nuclear respiratory factor-1 (NRF-1) site, and for GC boxes [1].
A 279 bp fragment of the CXCR4 promoter was shown to have a “tumor-on” status in vitro and in vivo particularly in melanoma and breast cancers [2].

 

References:

1. Moriuchi M. et al., 1997. Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. J Immunol. 159(9):4322-9.
2. Zhu ZB. et al., 2004. Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter. Gene Ther. 11(7):645-8.

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Specifications

pDRIVE bearing human CXCR4 promoter - LacZ, SEAP or Lucia
Gene Promoter: CXC-Chemokine receptor 4
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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