pDRIVE-hLP
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Cat.code:
pdrive-hlp
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ABOUT
L-plastin (LP) promoter in pDRIVE expression plasmid
L-plastin (LP) belongs to a family of genes that encode actin-binding proteins. LP is constitutively expressed at high levels in malignant epithelial cells but is not expressed in normal tissues, except at low levels in mature hematopoietic cells.
A 315-bp fragment of the 5’ region of the L-plastin gene, spanning the TATAAA box and a potential Sp1-binding site, is sufficient to exhibit strong promoter activity [1].
The L-plastin promoter driving the expression of a suicide gene was used to successfully inhibit the growth of ovarian tumor cells in vitro and in vivo [2].
References:
1. Lin CS. et al. 1993. Characterization of the human L-plastin gene promoter in normal and neoplastic cells. J Biol Chem 268(4):2793-801.
2. Peng XY et al. 2001. The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. Cancer Res 61(11):4405-13.
All products are for internal research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
in vitro or in vivo transfection
Tumor
in vitro transfection
Plasmid construct has been confirmed by restriction analysis and full-length ORF sequencing.
CONTENTS
Contents
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Product:pDRIVE-hLP
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Cat code:pdrive-hlp
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Quantity:20 µg
1 ml of Zeocin® (100 mg/ml)
Shipping & Storage
- Shipping method: Room temperature
- -20°C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Plasmid Map and Sequence
Safety Data Sheet
Plasmid Sequence
Certificate of analysis
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