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pDRIVE-LP

pDRIVE-hLP Unit size Cat. code Docs Qty Price
pDRIVE bearing human LP promoter - LacZ
20 µg
pdrive-hlp
+-
$433.00
pDRIVE5SEAP-hLP Unit size Cat. code Docs Qty Price
pDRIVE bearing human LP promoter - SEAP
20 µg
pdrive5s-hlp
+-
$433.00
pDRIVE5Lucia-hLP Unit size Cat. code Docs Qty Price
pDRIVE bearing human LP promoter - Lucia
20 µg
pdrive5lc-hlp
+-
$433.00

pDRIVE bearing human LP promoter - LacZ, SEAP or Lucia
Gene Promoter: L-Plastin (Lymphocyte cytosolic protein 1)
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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Contents

- Provided as 20 µg lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar).

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Description

L-plastin (LP) belongs to a family of genes which encode actin-binding proteins. LP is constitutively expressed at high levels in malignant epithelial cells but is not expressed in normal tissues, except at low levels in mature hematopoietic cells. A 315-bp fragment of the 5’ region of the L-plastin gene, spanning the TATAAA box and a potential Sp1-binding site, is sufficient to exhibit strong promoter activity [1]. The L-plastin promoter driving the expression of a suicide gene was used to successfully inhibit the growth of ovarian tumor cells in vitro and in vivo [2].

1. Lin CS. et al. 1993. Characterization of the human L-plastin gene promoter in normal and neoplastic cells. J Biol Chem 268(4):2793-801.
2. Peng XY et al. 2001. The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. Cancer Res 61(11):4405-13.

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Details

pDRIVE map

pDRIVE5-SEAP map

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