|pUNO1-hSTING-S154||Unit size||Cat. code||Docs||Qty||Price|
pUNO1 bearing the human STING gene, N154S variant
Expression-ready ORF Clones
SAVI-associated N154S hSTING gene
STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the interferon (IFN) response to microbial or self DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs) .
Several variants of STING have been described in the human population. The allele S154 contains a unique point mutation (N154S) in the “wild-type” R232-RGR hSTING variant.
This mutation confers gain-of-function and constitutive activation of STING with an upregulation of IFN production. It is associated with a chronic autoinflammatory disease, known as STING-associated vasculopathy with onset in infancy (SAVI) .
1. Sun L. et al., 2013. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 339:786-91.
2. Liu Y. et al., 2014. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 371(6):507-18.
Human STING-S154 (pUNO1-hSTING-S154)
ORF size : 1140 bp
Subclone : BspEI - NheIBack to the top
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.Back to the top