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SIGIRR

pUNO1-hSIGIRR Unit size Cat. code Docs Qty Price
pUNO1 bearing the human SIGIRR gene
20 µg
puno1-hsigirr
+-
$384.00
pUNO1-mSIGIRR Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse SIGIRR gene
20 µg
puno1-msigirr
+-
$384.00

Expression-ready ORF Clones

Alias : TIR8

Single ImmunoGlobulin IL-IR-Related molecule.

Single Ig IL-1R-related molecule (SIGIRR), also called TIR8, is a member of the Toll/IL-1 receptor (TIR) superfamily. SIGGIR is mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut [1]. It contains the typical conserved motifs that characterize the TIR superfamily, but is structurally and functionally distinct [2]. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice and cells from SIGIRR-deficient mice show enhanced activation in response to either IL-1 or certain TLR ligands [3]. These data suggest that SIGIRR functions as an important modulator of TLR/IL-1R signaling.

1. Polentarutti N. et al., 2003. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw. 14(4):211-8.
2. Thomassen E. et al., 1999. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 11(6):389-99.
3. Wald D. et al., 2003. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9):920-7.

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Specifications

Human SIGIRR (pUNO1-hSIGIRR)

Genbank : NM_021805.2
ORF size : 1233 bp
Subclone : AgeI - NheI

Mouse SIGIRR (pUNO1-mSIGIRR)

Genbank : NM_023059.3
ORF size : 1230 bp
Subclone : NcoI - EcoRI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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Citations

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