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CPPD Crystals

CPPD crystals Unit size Cat. code Docs Qty Price
Calcium Pyrophosphate Dihydrate crystals
5 mg
tlrl-cppd
+-
$135.00
available soon

NLRP3 Inflammasome Inducer

Calcium pyrophosphate dihydrate (CPPD) is the aetiological agent of the joint acute inflammatory disease pseudogout. CPPD crystals can act as endogenous danger signals that stimulate the innate immune system to produce inflammatory cytokines, such as IL-1β. CPPD crystals activate caspase-1, which is required for IL-1β maturation, through the NRLP3 (NALP3) inflammasome.

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Specifications

Working concentration: 1 - 50 µg/ml

CAS number: 7790-76-3

Molecular weight: 254.1

Structure: Triclinic crystals characterized by X-ray diffraction

Solubility: Not soluble

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Contents

• 5 mg calcium pyrophosphate dihydrate (CPPD) crystals

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Description

Calcium pyrophosphate dihydrate (CPPD) is the aetiological agent of the joint acute inflammatory disease pseudogout. Similarly to uric acid, the causative agent of gout, CPPD crystals can act as endogenous danger signals that stimulate the innate immune system to produce inflammatory cytokines such as interleukin (IL)-1β [1]. Recently, CPPD crystals were shown to activate caspase-1, which is required for IL-1β maturation, through the NRLP3 (NALP3) inflammasome [2]. The NLRP3 inflammasome is a caspase-1-activating complex comprising the NLR protein NLRP3 and the adaptor ASC [3]. Engagement of the NRLP3 inflammasome is supported by the finding that macrophages from mice deficient in various components of the inflammasome do not respond to injection of CPPD crystals [2].

1. Shi et al., 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425(6957):516-21
2. Martinon F. et al., 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 440(7081):237-41.
3. Martinon F, Tschopp J., 2004. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell. 117(5):561-74.

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Citations

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