Hemozoin
| Hemozoin | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
Synthetic heme crystal |
5 mg |
tlrl-hz |
NLRP3 Inflammasome Inducer - Synthetic heme crystal
Hemozoin is a dark-brown heme crystal produced by the intraerythrocytic parasite Plasmodium, the causative agent of malaria. Hemozoin is taken up by macrophages initiating signals that lead to the production of IL-1β.
Hemozoin-induced IL-1β production is dependent on the activation of the NLRP3 inflammasome [1,2]. Synthetic hemozoin has been shown to possess adjuvant properties that differ depending on the method of synthesis [3].
InvivoGen provides a chemically synthesized hemozoin using an acidic method.
References:
1. Shio MT. et al., 2009. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 5(8):e1000559.
2. Dostert C. et al., 2009. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One. 4(8):e6510.
3. Coban C. et al., 2010. The malarial metabolite hemozoin and its potential use as a vaccine adjuvant. Allergol Int. 59(2):115-24.
Specifications
Working concentration: 50 - 400 µg/ml
CAS number: 39404-00-7
Solubility: Insoluble. Rehydration of hemozoin with water or saline results in a dark brown suspension.
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Hemozoin is provided as solid dark-green to black crystals.
- 5 mg Hemozoin
Hemozoin is shipped at room temperature.
Store at -20°C