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Phorbol myristate acetate - NF-kB Activator
Phorbol myristate acetate. NF-κB Activator
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA) is a specific activator of Protein Kinase C (PKC) and hence of NF-κB.
PMA is the most commonly used phorbol ester. It is active at nanomolar concentrations.
PMA causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter.
Chang MS. et al., 2005. Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways. Cell Signal. 17(3):299-310.
Schindler U. & Baichwal VR., 1994. Three NF-kB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol Cell Biol, 14(9):5820-5831.
Working concentration: 100 ng - 1 µg/ml
CAS number: 16561-29-8
Molecular weight: 616.8
Solubility: DMSO (5 mg/ml)Back to the top
PMA is provided as a translucent film
- 5 mg Phorbol myristate acetate (PMA)
- 2 ml sterile endotoxin-free water
Product is shipped at room temperatureBack to the top