CLI-095

TLR4 signaling inhibitor

CLI-095, also known as TAK-242, is a novel cyclohexene derivative that suppresses specifically TLR4 signaling, inhibiting the production of NO and pro-inflammatory cytokines [1].

It acts by blocking the signaling mediated by the intracellular domain of TLR4, but not the extracellular domain.

It potently suppresses both ligand-dependent and -independent signaling of TLR4 [2].

References

1. Li M. et al., 2006. A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4- fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll- Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling. Mol. Pharmacol., 69:1288-1295.
2. Kawamoto T. et al., 2008. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol. 584(1):40-8.

Specifications

Working concentration: 50 nM - 5 μM

CAS number: 243984-11-4

Solubility: DMSO (1 mg/ml), Methanol (1 mg/ml)

Molecular weight: 361.82 g/mol

Contents

CLI-095 is provided as a solid.

• 1 mg CLI-095

CLI-095 is shipped at room temperature.

Store at -20°C.

Solid product is stable for 1 year when properly stored.