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codA::upp

pUNO1-codAupp Unit size Cat. code Docs Qty Price
pUNO1 bearing the bacterial codA::upp fusion gene
20 µg
puno1-codaupp
+-
$423.00

Expression-ready ORF Clones

 

E. coli Cytosine Deaminase fused to Uracil Phosphoribosyltransferase.

 

Cytosine deaminase (CD) is an enzyme found in prokaryotes and lower eukaryotes but absent in higher eukaryotes. It converts cytosine and its analog, 5-fluorocytosine (5-FC), to uracil and 5-fluorouracil (5-FU) respectively. 5-FU is a toxic compound commonly used as an anticancer drug.
To further increase the efficiency of the CD/5-FC pair, InvivoGen has fused the gene encoding uracil phosphoribosyl transferase to the CD gene. UPRT converts 5-FU to 5-FUMP, an irreversible inhibitor of thymidylate synthase.

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Specifications

Bacterial codA::upp (pUNO1-codAupp)

ORF size : 1935 bp
Subclone : NcoI - NheI

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pUNO1 Contents

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.

stability Resuspended DNA should be stored at -20°C and is stable for up to 1 year.

Alert Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.

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