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CLEC 7A

Product Unit size Cat. code Docs. Qty. Price

pUNO1-bCLEC7Aa

pUNO1 bearing the bovine CLEC7A (DECTIN1) gene, isoform_1

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20 µg

puno1-bclec7aa
+-
$473

pUNO1-bCLEC7Ab

pUNO1 bearing the bovine CLEC7A (DECTIN1) gene, isoform_2

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20 µg

puno1-bclec7ab
+-
$473

pUNO1-hCLEC7Aa

pUNO1 bearing the human CLEC7A (DECTIN1) gene, isoform_1 (longest)

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20 µg

puno1-hclec7aa
+-
$473

pUNO1-hCLEC7Ab

pUNO1 bearing the human CLEC7A (DECTIN1) gene, isoform_2 (major variant B)

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20 µg

puno1-hclec7ab
+-
$473

pUNO1-mCLEC7Aa

pUNO1 bearing the mouse CLEC7A (DECTIN1) gene, isoform_1

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20 µg

puno1-mclec7aa
+-
$473

pUNO1-mCLEC7Ab

pUNO1 bearing the mouse CLEC7A (DECTIN1) gene, isoform_2 (in RAW cell lines)

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20 µg

puno1-mclec7ab
+-
$473
  • About
  • Specifications
  • pUNO1 Contents

Expression-ready ORF Clones

Alias : CLEC7A, DECTIN1, CLECSF12, CD369, SCARE2

 

Dectin-1.
C-type lectin domain family 7, member A.
C-type lectin-like receptor superfamily 12B.

 

Dectin-1 is a C-type lectin expressed on phagocytic cells, including macrophages and neutrophils, that recognizes and responds to live fungal pathogens.
Dectin-1 mediates both the internalization and cellular responses to beta-glucan containing particles such as Zymosan, a cell wall preparation of Saccharomyces cerevisiae, through unique mechanisms [1]. Zymosan is also recognized by TLR2/TLR6 heterodimers which signaling mediates the activation of NF-kB and the production of inflammatory cytokines. Recent data suggest that Dectin-1 and TLR2/TLR6 signaling combine to enhance the responses triggered by each receptor [2,3].


1. Herre J. et al., 2004. The role of dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3):193-204.
2. Gantner BN. et al., 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J.Exp. Med. 197(9):1107-17.
3. Mukhopadhyay S. et al., 2004. The potential for Toll-like receptors to collaborate with other innate immune receptors. Immunology.112(4):521-30.

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Specifications

Bovine CLEC7A isoform_1 (pUNO1-bCLEC7Aa)

ORF size : 744 bp
Subclone : AgeI - NheI

Bovine CLEC7A isoform_2 (pUNO1-bCLEC7Ab)

ORF size : 606 bp
Subclone : AgeI - NheI

Human CLEC7A isoform 1 (longest) (pUNO1-hCLEC7Aa)

ORF size : 744 bp
Subclone : AgeI - NheI

Human CLEC7A isoform 2 (major variant B) (pUNO1-hCLEC7Ab)

Genbank : NM_022570.4
ORF size : 606 bp
Subclone : AgeI - NheI

Mouse CLEC7A isoform_1 (pUNO1-mCLEC7Aa)

ORF size : 735 bp
Subclone : BspHI - NheI

Mouse CLEC7A isoform_2 (pUNO1-mCLEC7Ab)

ORF size : 600 bp
Subclone : BspHI - NheI

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pUNO1 Contents

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.

stability Resuspended DNA should be stored at -20°C and is stable for up to 1 year.

Alert Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.

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