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CD180

Product Unit size Cat. code Docs. Qty. Price

pUNO1-hCD180

pUNO1 bearing the human CD180 (RP105) gene

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20 µg

puno1-hcd180
+-
$473

pUNO1-mCD180

pUNO1 bearing the mouse CD180 (RP105) gene

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20 µg

puno1-mcd180
+-
$473
  • About
  • Specifications
  • pUNO1 Contents

Expression-ready ORF Clones

Alias : RP105, Ly78, Ly64

 

Radioprotective, 105kD.
CD180 molecule.
CD180 antigen.
Lymphocyte antigen 64 (mouse) homolog.

 

CD180 (RP105), a TLR-related protein, was identified in B cells and acts as both an LPS sensor and a regulator of B cell proliferation [1]. B-cells lacking CD180 were shown to be severely impaired in LPS-induced proliferation and antibody production. Like TLR4, CD180 requires a MD2-related protein, MD1, for its surface expression. Furthermore, the expression of CD180 was reported to strongly increase during differentiation, suggesting that CD180 is also important in monocyte function [2].

1. Miyake K. et al., 2000. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1. J Endotoxin Res, 6(5):389-91
2. Zarember A. and PJ. Godowski, 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol, 168(2):554-61

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Specifications

Human CD180 (pUNO1-hCD180)

Genbank : AK313177.1
ORF size : 1986 bp
Subclone : NcoI - NheI

Mouse CD180 (pUNO1-mCD180)

Genbank : D37797.1
ORF size : 1986 bp
Subclone : NcoI - NheI

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pUNO1 Contents

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.

stability Resuspended DNA should be stored at -20°C and is stable for up to 1 year.

Alert Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.

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