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COVID-19

Spotlight on COVID-19: Infection

Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly around the world, causing a pandemic that threatens global public health. The causative agent of COVID-19 is Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel β-coronavirus. Globally, the number of positive COVID-19 cases grows exponentially every day and now the race is on to find both an effective treatment and to develop a vaccine for prevention measures in the future.

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Previous reviews

Innate Immunity / PRR

Multi-TLR Agonists: Potential for Therapeutic Success

Toll-like receptors (TLRs) are the best studied pattern recognition receptors (PRRs) and their importance in stimulating innate and adaptive immunity is now well established.
TLRs are sensors of microbial components as well as host-derived endogenous molecules released by injured tissues. TLRs play a critical role in defense against invading pathogens but are also involved in other...

Innate Immunity / STING / Vaccination

STING in Vaccine Adjuvants

Adjuvants enhance and direct the adaptive immune response to vaccine antigens through various mechanisms, some of which are still poorly understood. Recently, STING and more generally the host nucleic acid sensing machinery were shown to play an essential role in vaccination.

Innate Immunity

Innate Immunity

The innate immune system is an evolutionarily conserved system acting as a first-line of defense against invading microbial pathogens and other potential threats to the host.

Innate Immunity / Inflammasome

Inflammasomes

The nucleotide-binding oligomerization domain-like receptor (NLR) family of proteins is involved in the regulation of innate immunity responses.

Products

Introducing Lucia: a new secreted luciferase

Luciferases encompass a wide range of enzymes used for bioluminescence, the emission of light produced by a living organism. Luciferases are highly prized bioindicators for life science research and drug discovery, owing to their remarkable sensitivity, lack of toxicity and wide dynamic range of quantitation.

Innate Immunity / PRR

Nod-Like Receptors

The cytosolic NOD-Like Receptors (NLRs, also known as CATERPILLERs, NODs or NALP/PAN/PYPAFs) are nucleotide-binding oligomerization domain containing receptors.

Innate Immunity / PRR / STING

Cytosolic DNA Sensors (CDSs): a STING in the tail

The innate immune system provides the first line of defense against infectious pathogens and serves to limit their early proliferation. It is also vital in priming and activating the adaptive immune system.

Innate Immunity / PRR

Toll-Like Receptors

Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals.

Innate Immunity / PRR

C-Type Lectin Receptors

C-type lectin receptors (CLRs) comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner.

Innate Immunity / PRR

RIG-I-Like Receptors & Cytosolic DNA Sensors

RIG-I-like receptors (RLRs) constitute a family of cytoplasmic RNA helicases that are critical for host antiviral responses.

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