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Innate Immunity / PRR / Inflammasome

NLRP3: a sophisticated drug target

NLRP3 (NOD-like receptor pyrin domain-containing protein 3, cryopyrin or NALP3) is the best described inflammasome sensor and an attractive drug target. NLRP3 assembles into a multiprotein inflammasome complex to induce the secretion of IL-1β/IL-18 and pyroptosis in response to infections and cellular damage. However, NLRP3 inflammasome functions can also be detrimental to the host, as its abberant or chronic activation is linked with pathologies such as type-2 diabetes, gouty arthritis, cardiovascular and Alzheimer’s diseases, and rare genetic disorders such as CAPS (cryopyrin-associated-periodic-syndrome). Fast-paced research now aims at filling the gaps in the comprehension of NLRP3 inflammasome activation and regulation to develop novel therapeutics.

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Previous reviews

Innate Immunity

Innate Immunity

The innate immune system is an evolutionarily conserved system acting as a first-line of defense against invading microbial pathogens and other potential threats to the host.

Innate Immunity / Inflammasome

Inflammasomes

The nucleotide-binding oligomerization domain-like receptor (NLR) family of proteins is involved in the regulation of innate immunity responses.

Products

Introducing Lucia: a new secreted luciferase

Luciferases encompass a wide range of enzymes used for bioluminescence, the emission of light produced by a living organism. Luciferases are highly prized bioindicators for life science research and drug discovery, owing to their remarkable sensitivity, lack of toxicity and wide dynamic range of quantitation.

Innate Immunity / PRR

Nod-Like Receptors

The cytosolic NOD-Like Receptors (NLRs, also known as CATERPILLERs, NODs or NALP/PAN/PYPAFs) are nucleotide-binding oligomerization domain containing receptors.

Innate Immunity / PRR / STING

Cytosolic DNA Sensors (CDSs): a STING in the tail

The innate immune system provides the first line of defense against infectious pathogens and serves to limit their early proliferation. It is also vital in priming and activating the adaptive immune system.

Innate Immunity / PRR

Toll-Like Receptors

Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals.

Innate Immunity / PRR

C-Type Lectin Receptors

C-type lectin receptors (CLRs) comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner.

Innate Immunity / PRR

RIG-I-Like Receptors & Cytosolic DNA Sensors

RIG-I-like receptors (RLRs) constitute a family of cytoplasmic RNA helicases that are critical for host antiviral responses.

Vaccination

Vaccine Adjuvants review

Adjuvants are essential for enhancing and directing the adaptative immune response to vaccine antigens. This response is mediated by two main types of lymphocytes, B and T cells.

Vaccination

Immunoglobulin A (IgA)

The mucosal surfaces represent the largest area of exposure of the body to external pathogens. Immunoglobulin A (IgA), in its secretory form, is the main effector of the mucosal immune system and provides an important first line of defense against most pathogens that invade the body at a mucosal surface [1].

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