InvivoGen’s Reviews
Inflammasome
NLRP1 & NLRP3: a tale of two inflammasome sensors
In this first newsletter of 2023, InvivoGen highlights the current knowledge about the NLRP1 and NLRP3 inflammasome sensors and discusses the experimental difficulty in assessing their respective role in pathophysiological contexts.
We also introduce a series of new products, including NLRP1 reporter cell lines, TLR4 reporter cell lines, as well as a new liquid formulation of our highly-cited luciferase detection reagent, QUANTI-Luc 4 Lucia/Gaussia.
Previous reviews
Innate Immunity / PRR
TLR7 and TLR8: Key players in the antiviral response
TLR7 and TLR8 are phylogenetically and structurally related. TLR7 is predominantly expressed in lung, placenta, and spleen, while TLR8 is predominantly expressed in lung and peripheral blood leukocytes, in particular monocytes.
Products
RNA Interference
RNA interference (RNAi) is one of the most exciting discoveries of the past decade in functional genomics. RNAi is rapidly becoming an important method for analyzing gene functions in eukaryotes and holds promise for the development of therapeutic gene silencing.
Innate Immunity
Type I IFN Production and Signaling
The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections, as well as activating key components of the innate and adaptive immune systems including antigen presentation and...
Innate Immunity / PRR / IFN response
Toll-Like Receptors and Viral Infection
Toll-like receptors (TLRs) are essential for the recognition of microbial pathogens. A subset of TLRs, TLR3, TLR7/8, and TLR9, is involved in antiviral responses by triggering the production of antiviral cytokines such as type I interferons (IFNs). TLR3 responds to double stranded RNA, a replication intermediary for many viruses. TLR7/8 recognize viral single-stranded RNAs, whereas TLR9...
Innate Immunity / PRR
TLR9 Recognition and Signaling: An Update
Toll-like receptor 9 (TLR9) recognizes unmethylated bacterial CpG DNA and initiates a signaling cascade leading to the production of proinflammatory cytokines.
Products
pCpGfree vitro, A New Family of CpG-free Plasmids
pCpGvitro is a new family of expression vectors completely devoid of CpG dinucleotides that are selectable in mammalian cells.
Innate Immunity / PRR
Toll-like Receptor 11
To date, ten mammalian Toll-like receptors (TLRs) have been identified. They recognize specific molecular patterns associated with microbial pathogens and induce the activation of host-defense genes.