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COVID-19

Spotlight on COVID-19: Vaccine development

Globally, the vaccine development effort in response to the COVID-19 pandemic is unprecedented in terms of both scale and speed. Importantly, SARS-CoV-2 vaccines will be essential in reducing morbidity and mortality if/when the virus establishes itself in the population. The race is now on for the development of both a safe and, effective vaccine against SARS-CoV-2.

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Innate Immunity

Type I IFN Production and Signaling

The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections, as well as activating key components of the innate and adaptive immune systems including antigen presentation and...

Innate Immunity / PRR / IFN response

Toll-Like Receptors and Viral Infection

Toll-like receptors (TLRs) are essential for the recognition of microbial pathogens. A subset of TLRs, TLR3, TLR7/8, and TLR9, is involved in antiviral responses by triggering the production of antiviral cytokines such as type I interferons (IFNs). TLR3 responds to double stranded RNA, a replication intermediary for many viruses. TLR7/8 recognize viral single-stranded RNAs, whereas TLR9...

Innate Immunity / PRR

TLR9 Recognition and Signaling: An Update

Toll-like receptor 9 (TLR9) recognizes unmethylated bacterial CpG DNA and initiates a signaling cascade leading to the production of proinflammatory cytokines.

Products

pCpGfree vitro, A New Family of CpG-free Plasmids

pCpGvitro is a new family of expression vectors completely devoid of CpG dinucleotides that are selectable in mammalian cells.

Innate Immunity / PRR

Toll-like Receptor 11

To date, ten mammalian Toll-like receptors (TLRs) have been identified. They recognize specific molecular patterns associated with microbial pathogens and induce the activation of host-defense genes.

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