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Innate Immunity

TLR7 & TLR8: fraternal twins

Toll-like receptors (TLRs) play a pivotal role in the initiation of anti-infectious immune responses. Distinct pathogen-associated molecular patterns (PAMPs) are recognized by different TLRs, at the cell surface or in endosomes. TLR7 and TLR8 are endosomal receptors that share structural homology and sense viral single stranded (ss) RNA as well as synthetic base analogs. However, there are functional differences between these two TLRs.

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Innate Immunity / PRR

Toll-like Receptor 11

To date, ten mammalian Toll-like receptors (TLRs) have been identified. They recognize specific molecular patterns associated with microbial pathogens and induce the activation of host-defense genes.

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