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COVID-19

Spotlight on COVID-19: Protective immunity & Re-infection

As our understanding of COVID-19 continuously progresses, some essential questions remain open including "Does protective immunity develop after SARS-CoV-2 infection?" and "How long does it last?" There is growing evidence that re-infection by SARS-CoV-2 can occur, indicating that immunity is either not strong enough, or not long-lasting in all individuals. Therefore, it is crucial to elucidate the conditions entailing re-infection, to better apprehend the development of an effective vaccine against SARS-Cov-2.

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Products

RNA Interference

RNA interference (RNAi) is one of the most exciting discoveries of the past decade in functional genomics. RNAi is rapidly becoming an important method for analyzing gene functions in eukaryotes and holds promise for the development of therapeutic gene silencing.

Innate Immunity

Type I IFN Production and Signaling

The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections, as well as activating key components of the innate and adaptive immune systems including antigen presentation and...

Innate Immunity / PRR / IFN response

Toll-Like Receptors and Viral Infection

Toll-like receptors (TLRs) are essential for the recognition of microbial pathogens. A subset of TLRs, TLR3, TLR7/8, and TLR9, is involved in antiviral responses by triggering the production of antiviral cytokines such as type I interferons (IFNs). TLR3 responds to double stranded RNA, a replication intermediary for many viruses. TLR7/8 recognize viral single-stranded RNAs, whereas TLR9...

Innate Immunity / PRR

TLR9 Recognition and Signaling: An Update

Toll-like receptor 9 (TLR9) recognizes unmethylated bacterial CpG DNA and initiates a signaling cascade leading to the production of proinflammatory cytokines.

Products

pCpGfree vitro, A New Family of CpG-free Plasmids

pCpGvitro is a new family of expression vectors completely devoid of CpG dinucleotides that are selectable in mammalian cells.

Innate Immunity / PRR

Toll-like Receptor 11

To date, ten mammalian Toll-like receptors (TLRs) have been identified. They recognize specific molecular patterns associated with microbial pathogens and induce the activation of host-defense genes.

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