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Loxoribine

Loxoribine Unit size Cat. code Docs Qty Price
Guanosine analog
50 mg
tlrl-lox
+-
$161.00

TLR7 Agonist - Guanosine analog

Loxoribine is a guanosine analog derivatized at position N7 and C8. This nucleoside is a very powerful stimulator of the immune system but until recently the mechanism responsible for this immunostimulatory activity was unknown [1]. It appears that similarly to imiquimod, a small synthetic antiviral molecule, loxoribine activates the innate immune system through Toll-like receptor 7 and that this activation requires endosomal maturation [2]. Loxoribine recognition is restricted to TLR7.

1. Gorden KB. et al., 2005. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol. 174(3):1259-68.

2. Heil F. et al., 2003. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 33(11):2987-97.

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Specifications

Working concentration: 1 mM (300 µg/ml)

CAS number: 121288-39-9

Specificity: human/mouse TLR7 agonist

Solubility: 100 mM in DMSO

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Contents

•  50 mg (147 μmol) Loxoribine
•  25 ml sterile endotoxin-free water

Loxoribine is provided as a white to off-white solid and shipped at room temperature. Store product at 4°C.

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Citations

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