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TLR7 Agonist - Guanosine analog
Loxoribine is a guanosine analog derivatized at position N7 and C8. This nucleoside is a very powerful stimulator of the immune system but until recently the mechanism responsible for this immunostimulatory activity was unknown . It appears that similarly to imiquimod, a small synthetic antiviral molecule, loxoribine activates the innate immune system through Toll-like receptor 7 and that this activation requires endosomal maturation . Loxoribine recognition is restricted to TLR7.
1. Gorden KB. et al., 2005. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol. 174(3):1259-68.
2. Heil F. et al., 2003. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 33(11):2987-97.
Working concentration: 1 mM (300 µg/ml)
CAS number: 121288-39-9
Specificity: human/mouse TLR7 agonist
Solubility: 100 mM in DMSOBack to the top
• 50 mg (147 μmol) Loxoribine
• 25 ml sterile endotoxin-free water
Loxoribine is provided as a white to off-white solid and shipped at room temperature. Store product at 4°C.Back to the top