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CL097

CL097 Unit size Cat. code Docs Qty Price
Imidazoquinoline compound
500 µg
5 mg
tlrl-c97
+-
$145.00

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TLR7/8 Agonist - Imidazoquinoline compound

CL097 is a highly water-soluble derivative of the imidazoquinoline compound R848 (Resiquimod). Like R848, CL097 induces TLR7 and/or TLR8  responses in human and murine immune cells [1, 2].

CL097 has been described as a preferential TLR7 agonist [1]. CL097 has been shown as a strong inducer of plasmacytoid dendritic cells (pDCs) activation, which represents a key therapeutic axis for cancer or other diseases [2].

We confirmed the TLR7/8 agonist activity of CL097 using our reporter cell lines HEK-Blue™ hTLR7HEK-Blue™ hTLR8HEK-Dual™ mTLR7, and HEK-Blue™ mTLR8. CL097 is a more potent hTLR7 agonist than other TLR7/8 agonists, including CL075, and TLR7 agonists, such as Gardiquimod, Imiquimod, Loxoribine, and CL264. However, CL097 is a less potent hTLR8 agonist than CL075 and the TLR8 agonist TL8-506. CL097 also activates murine TLR7 (mTLR7), but not mTLR8.  

 

Key features of CL097:

  • Agonist of hTLR7 and hTLR8 with higher potency towards hTLR7.
  • Agonist of mTLR7.
  • Each lot of CL097 is highly pure (>95%) and functionally tested.

 

References:

1. Schön M.P. & Schön M., 2008. TLR7 and TLR8 as targets in cancer therapy. Oncogene. 27:190-199.
2. Wu J. et al., 2019. pDC activation by TLR7/8 ligand CL097 compared to TLR7 ligand IMQ or TLR9 ligand CpG.  J. Immunol. Res. ID:1749803.

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Specifications

Specificity: human TLR7/8 and mouse TLR7 agonist

CAS number: 1026249-18-2

Formula: C13H14N4O 

Molecular weight: 242.28 g/mol

Solubility: 1 mg/ml in water

Working Concentration:

  • 0.3 - 3 μg/ml CL097 for human TLR8 and mouse TLR7 in cell culture assays
  • 50 ng - 3 μg/ml CL097 for human TLR7 in cell culture assays

Quality control:

  • Purity: ≥95% (UHPLC)
  • The biological activity of CL097 has been verified using cellular assays.
  • The absence of bacterial contamination has been confirmed using HEK-Blue™ hTLR2 cells (for lipoproteins) and HEK-Blue™ hTLR4 cells (for endotoxins).
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Contents

CL097 is available in two quantities:

tlrl-c97:

  • 500 µg CL097
  • 1.5 ml of sterile endotoxin-free water

tlrl-c97-5:

  • 5 mg CL097
  • 10 ml of sterile endotoxin-free water

room temperature CL097 is provided as a pale yellow solid and shipped at room temperature.

store Store at -20 ̊C.

stability Lyophilized product is stable for 1 year at -20°C when properly stored.

Resuspended CL097 should be aliquoted and stored at -20 ̊C.

Resuspended product is stable 6 months at -20°C.

Alert Avoid repeated freeze-thaw cycles.

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Details

Chemical structure of CL097: 

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Citations

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