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CL264

CL264 Unit size Cat. code Docs Qty Price
Adenine analog
500 µg
5 mg
tlrl-c264e
+-
$102.00

TLR7 Agonist - Adenine analog

CL264 is a 9-benzyl-8 hydroxyadenine derivative containing a glycine on the benzyl group (in para).
Similarly to SM360320, CL264 induces the activation of NF-κB and the secretion of IFN-α in TLR7- expressing cells.
CL264 is a TLR7-specific ligand, it does not stimulate TLR8 even at high concentrations (> 10 µg/ml).
In TLR7- transfected HEK293 cells, CL264 triggers NF-κB activation at a concentration of 0.1 µM which is 5-10 times less than imiquimod.

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Specifications

Specificity: human/mouse TLR7 agonist
Working concentration:
50 ng- 10 µg/ml
Endotoxin level:
EndoFit™ (<0.001 EU/μg)
Solubility:
1 mg/ml in water
Formula: C47H73N13O7S
Molecular weight:
413.43

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Contents

• CL264 is available in two quantities:
- 500 µg CL264: tlrl-c264e
- 5 mg CL264: tlrl-c264e-5

• sterile endotoxin-free water, 2 ml with #tlrl-c264e and 10 ml with #tlrl-c264e-5.

CL264 is provided as a white lyophilized powder and shipped at room temperature. Store at -20°C. Upon resuspension, prepare aliquots of CL264 and store at -20°C  Lyophilized product is stable 1 year at -20°C when properly stored. Resuspended product is stable 6 months at -20°C. Avoid repeated freeze-thaw cycles.

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Citations

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