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CL264

CL264 Unit size Cat. code Docs Qty Price
Adenine analog
500 µg
5 mg
tlrl-c264e
+-
$106.00

TLR7 Agonist - Adenine analog

CL264 is a 9-benzyl-8 hydroxyadenine derivative containing a glycine on the benzyl group (in para).

Similarly to SM360320, CL264 induces the activation of NF-κB and the secretion of IFN-α in TLR7- expressing cells.

CL264 is a TLR7-specific ligand, it does not stimulate TLR8 even at high concentrations (> 10 µg/ml).

In TLR7- transfected HEK293 cells, CL264 triggers NF-κB activation at a concentration of 0.1 µM which is 5-10 times less than imiquimod.

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Specifications

Specificity: human/mouse TLR7 agonist

Working concentration: 50 ng- 10 µg/ml

Solubility: 1 mg/ml in water

Formula: C47H73N13O7S

Molecular weight: 413.43 g/mol

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Contents

CL264 is provided as a lyophilized powder and available in two quantities:

Catalog code : tlrl-c264e

  • 500 µg CL264
  • 1.5 ml of sterile endotoxin-free water

Catalog code : tlrl-c264e-5

  • 5 mg CL264
  • 10 ml of sterile endotoxin-free water

room temperature CL264 is shipped at room temperature.

store Upon receipt, store at -20°C. 

stability Lyophilized product is stable for 1 year at -20°C. 

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Citations

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