CL264
| CL264 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
Adenine analog |
500 µg 5 mg |
tlrl-c264e |
TLR7 Agonist - Adenine analog
CL264 is a 9-benzyl-8 hydroxyadenine derivative containing a glycine on the benzyl group (in para).
Similarly to SM360320, CL264 induces the activation of NF-κB and the secretion of IFN-α in TLR7- expressing cells.
CL264 is a TLR7-specific ligand, it does not stimulate TLR8 even at high concentrations (> 10 µg/ml).
In TLR7- transfected HEK293 cells, CL264 triggers NF-κB activation at a concentration of 0.1 µM which is 5-10 times less than imiquimod.
Back to the topSpecifications
Specificity: human/mouse TLR7 agonist
Working concentration: 50 ng- 10 µg/ml
Solubility: 1 mg/ml in water
Formula: C47H73N13O7S
Molecular weight: 413.43 g/mol
Back to the topContents
CL264 is provided as a lyophilized powder and available in two quantities:
Catalog code : tlrl-c264e
- 500 µg CL264
- 1.5 ml of sterile endotoxin-free water
Catalog code : tlrl-c264e-5
- 5 mg CL264
- 10 ml of sterile endotoxin-free water
CL264 is shipped at room temperature.
Upon receipt, store at -20°C.
Lyophilized product is stable for 1 year at -20°C.