TL8-506
| TL8-506 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
Benzoazepine analog - TLR8 ligand |
500 µg |
tlrl-tl8506 |
Benzoazepine analog - TLR8 ligand
TL8-506 is a benzoazepine compound, analog of the Toll-like receptor 8 (TLR8) agonist VTX-2337 [1,2].
TL8-506 activates TLR8 more potently than the imidazoquinoline R848 (TLR7/8) and the thiazoquinolone CL075 (TLR8/7).
TL8-506 is ~50x and ~25x more potent in inducing NF-κB activation in TLR8-transfected HEK293 (HEK-Blue™ hTLR8) cells than R848 and CL075 (EC50, ~30 nM vs. ~1500 nM and 800 nM), respectively.
TL8-506 is a selective agonist of TLR8, it is ~500x more active on HEK-Blue hTLR8 than TLR7-transfected HEK293 (HEK-Blue™ hTLR7) cells (EC50, ~30 nM vs. ~15 μM).
TL8-506 has been formulated to increase its solubility in water.
References:
1. Lu H. et al., 2012. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 18(2):499-509.
2. Elavazhagan S. et al., 2015. Granzyme B Expression Is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to Antibody-Dependent Cellular Cytotoxicity. J Immunol. 194(6):2786-95.
Figures
Specifications
Specificity: TLR8 agonist
CAS number: 1268163-15-0
Solubility: water
Formula: C20H17N3O2
Molecular weight: 331.37
Contents
- 500 µg TL8-506
- 1.5 ml sterile endotoxin-free water
TL8-506 is provided lyophilized and shipped at room temperature.
Store at -20°C.