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TL8-506

TL8-506 Unit size Cat. code Docs Qty Price
Benzoazepine analog - TLR8 ligand
500 µg
tlrl-tl8506
+-
$168.00

Benzoazepine analog - TLR8 ligand

TL8-506 is a benzoazepine compound, analog of the Toll-like receptor 8 (TLR8) agonist VTX-2337 [1,2].

TL8-506 activates TLR8 more potently than the imidazoquinoline R848 (TLR7/8) and the thiazoquinolone CL075 (TLR8/7).

TL8-506 is ~50x and ~25x more potent in inducing NF-κB activation in TLR8-transfected HEK293 (HEK-Blue™ hTLR8) cells than R848 and CL075 (EC50, ~30 nM vs. ~1500 nM and 800 nM), respectively.

TL8-506 is a selective agonist of TLR8, it is ~500x more active on HEK-Blue hTLR8 than TLR7-transfected HEK293 (HEK-Blue™ hTLR7) cells (EC50, ~30 nM vs. ~15 μM).

TL8-506 has been formulated to increase its solubility in water.

 

References:

1. Lu H. et al., 2012. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 18(2):499-509.
2. Elavazhagan S. et al., 2015. Granzyme B Expression Is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to Antibody-Dependent Cellular Cytotoxicity. J Immunol. 194(6):2786-95.

Figures


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Specifications

Specificity: TLR8 agonist
CAS number: 1268163-15-0
Solubility: water
Formula:
C20H17N3O2
Molecular weight: 
331.37

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Contents

  • 500 µg TL8-506
  • 1.5 ml sterile endotoxin-free water

room temperature TL8-506 is provided lyophilized and shipped at room temperature.

store Store at -20°C.

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Citations

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