Toll-like receptor (TLR) 7 and TLR8 play an important role in the immune response to viral infection. They recognize single stranded RNAs as their natural ligand and also small synthetic molecules such as imidazoquinolines and nucleoside analogs.
InvivoGen provides the most comprehensive choice of ligands known to activate TLR7/8.
For vaccination studies, InvivoGen supplies the TLR7/8 ligands, Gardiquimod, Imiquimod and R848 (resiquimod) VacciGrade™ (preclinical grade: sterile and endotoxin level).
The activity of these TLR ligands is tested using HEK-Blue™ TLR7 and HEK-Blue™ TLR8 Cells.